Objective: The aim of the present study was to investigate the effect of antihyperlipidemic activity of ethyl acetate extract of Commiphora mukul (EECM) gum resin and compares its efficacy with that of atorvastatin against atherogenic diet-induced hyperlipidemia model using rat as an experimental animal.Methods: Wistar albino rats were divided into five groups. Control animals received normal diet, hyperlipidemic control; rats treated with EECM 100 and 200 mg/kg and positive control, receiving standard drug atorvastatin 2.70 mg/kg.
Results:Increase the level of serum cholesterol, phospholipids, high-density lipoproteins, low-density lipoproteins, and triglycerides causing hyperlipidemia further leading to the development of atherosclerosis. On the other hand, oral administration of ethyl acetate extract of C. mukul at dose of 200 mg/kg for 15 days resulted in the prevention of above abnormalities.
Conclusion:The results suggest that EECM could be beneficial in the treatment of atherosclerosis, characterized by atherogenic lipoprotein profile and abnormalities in lipid metabolism.
Slow evaporation method at constant temperature was used to generate optically better-quality clove and pure doped Potassium Di-hydrogen Phosphate crystals, which were then characterized. If the optimum conditions are adequately attained, the slow evaporation method can be used to produce crystals with low solubility. FTIR spectra are used to assess the reality of crystal efficient groups qualitatively. To investigate the dopants effect on the ideal appearances of Potassium Di-hydrogen Phosphate, an X-ray diffraction investigation was carried out. The tetragonal design of KDP and incapacitated crystals was discovered via powdered X-ray diffraction. The lattice parameter values were determined using X-ray diffraction on a single crystal. UV-Visible spectroscopy was used to examine the generated clove doped (1:1) KDP crystals. The TG and DTA analysis were utilized to examine the constancy and breakdown of unpolluted and clove doped KDP crystals. ND-YAG laser was utilized to notice the SHG. Clove doped KDP crystals outperformed pure KDP crystals in terms of relative generation of second harmonics productivity. The effect of dopants on the exterior morphology of KDP crystals was investigated using a scanning electron microscope (SEM). EDAX was utilized to have a better understanding of the elements found in crystals.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.