This report highlights a complication never seen in the literature of a relatively rare condition. In our case, the combined approach was effective for both clinical control and lesion regression.
ResumenLa resección guiada por fluorescencia con ácido aminolevulínico (5-ALA) se ha demostrado útil para el tratamiento quirúrgico de los gliomas cerebrales malignos. También parece útil en el tratamiento de otros tipos de tumores, tanto cerebrales como intramedulares. Presentamos el caso de un paciente con un tumor intramedular en el que la fluorescencia con 5-ALA fue de utilidad para la localización intraoperatoria de la lesión, para la identificación de pequeños nódulos en el parénquima medular y para lograr la exéresis completa del tumor.PALABRAS CLAVE: Ácido aminolevulínico. 5-ALA. Ependimoma. Fluorescencia. Tumor intramedular. IntroducciónLa resección guiada por fluorescencia con ácido aminolevulínico (5-ALA) trata de aprovechar la capacidad de algunos tejidos tumorales de acumular porfirinas fluorescentes que se hacen visibles en el campo quirúrgico con una coloración diferente al tejido normal cuando se utiliza una luz de una longitud de onda adecuada. Esta técnica está perfectamente establecida para el tratamiento quirúrgico de los gliomas cerebrales malignos 1,6-8 y, aunque aún no está disponible en muchos centros, está en pleno desarrollo al haber demostrado mejores tasas de resección completa en este tipo de tumores 8 . Se han publicado casos de otros tipos de tumores en los que la fluorescencia con 5-ALA puede ser útil para conseguir resecciones completas sin dejar restos tumorales que puedan pasar inadvertidos durante la cirugía. Es el caso de meningiomas invasivos 3,4 , metástasis cerebrales 9 e, incluso, tumores intramedulares 1,5 . En este trabajo presentamos un caso de tumor intramedular que fue tratado quirúrgicamente en nuestro servicio, en el que la fluorescencia con 5-ALA fue de utilidad para la localización intraoperatoria y la exéresis completa de la lesión. Caso clínicoMujer de 55 años de edad, con clínica de parestesias de 3 años de evolución que comenzaron inicialmente por extremidad superior izquierda, extendiéndose posteriormente a extremidad superior derecha y extremidad inferior izquierda. Año y medio después se añadió debilidad progresiva de extremidades izquierdas, espasmos musculares e incontinencia urinaria. Se realizó una resonancia magnética (RM) cervical que mostró un engrosamiento de la médula a nivel C1-C2 en las secuencias potenciadas en T1, con captación intensa y homogénea de contraste paramagnético (Figura 1). En las imágenes potenciadas en T2 la lesión se apreció como isointensa, con una hiperintensidad perilesional secundaria a edema que llegaba hasta C5-C6. Los hallazgos fueron compatibles con astrocitoma o ependimoma.
Traumatic cervical severe spondylolisthesis is a rare and severe lesion which is typically associated with a spinal cord injury. Nevertheless, it occasionally has a pauci-symptomatic course which may delay its diagnosis. The authors report an exceptional case of a 33-year-old woman who had mild spasticity in her lower limbs and neck pain 9 months after a traffic accident. The computed tomographic scan and magnetic resonance image revealed C7-T1 grade III spondylolisthesis and spinal cord signal change. The initial cervical traction did not obtain a spinal realignment. An anterior-posterior approach was performed to achieve a correct spinal fusion. After 18 months of follow-up care, the patient's symptoms improved significantly and she began to lead a normal life again. The case underlines the importance of performing a correct initial diagnostic workup upon a patient. This would improve surgical management by avoiding a worsening of the initial neurological deficit during the realignment maneuvers in the chronic grade III, IV or V spondylolisthesis. Case ReportTraumatic subaxial cervical luxations are typically produced by high-energy mechanisms and are associated with major spinal cord injury and mechanical instability. Cervicothoracic spondyloptosis or severe spondylolisthesis is an especially severe injury, usually with an easy diagnosis in the initial evaluation of a traumatic patient. Although there are cases reported of neurologically intact patients, the delay in the diagnosis is extremely rare (1,2). We present a case of a C7-T1 grade III spondylolisthesis identified 9 months after the traumatic event with mild progressive pyramidal symptoms in the lower limbs.The initial management of these fractures is generally a cervical traction to achieve a closed reduction that may allow a subsequent spinal stabilization with an anterior, posterior or combined approach (1-12). Nevertheless, in the chronic spondyloptosis (4) or high grade spondylolisthesis the treatment of the patient became a challenge to achieve a correct spinal alignment avoiding the worsening of the neurological status. Case presentationA 33-year-old female, without other medical pathologies or neurological damages, was admitted to the emergency room after a road traffic collision. The initial neurological examination was normal. The cervical spine plain radiography, in which the cervicothoracic union was not well defined, was considered normal (Figure 1). The patient was discharged with mild cervical pain. The pain remained approximately 8 weeks after the accident but no more radiological exams were made. Progressive subjective mild motor weakness and numbness of the lower limbs appeared progressively six-seven later. Nine months after the accident she was evaluated by a neurologist. The J Spine Surg 2017;3(1):82-86 jss.amegroups.com exploration revealed brisk reflexes in her lower limbs and decreased sensation at level at C7; there were no objective motor deficits (ASIA score D). The cervicothoracic MRI and CT (Figures 2,3) showed a C7-T1 tr...
Background: Ankylosing spondylitis (AS) is associated with high rates of severe thoracolumbar fractures, in many cases with neurological deficits. It is currently a point of debate as to whether the optimal surgical treatment is posterior fixation and fusion or combined approaches. Vascular injuries in this kind of fracture are a challenging issue to solve in the management of these patients.Methods: We are reporting the case of a 65-year-old man who presented an L4 traumatic fracture-dislocation. He had a long history of symptomatic AS. No neurological deficits were detected during the initial exploration. During the preoperative work-up, a lumbar spine computed tomography (CT) scan was taken with vascular reconstruction of the abdominal vessels. It confirmed the compression of the abdominal aorta, which had caused more than 90% stenosis. A posterior approach, an open reduction, and fixation with pedicle screws were performed, without hemodynamic or neurological changes. A postoperative angiography demonstrated a complete recovery of the vessel caliber, without contrast leaks.Results: After a 2-year follow-up, the patient was pain free and the CT scan revealed bone fusion. Conclusions:The vascular structures involved in severe thoracolumbar fractures present a dangerous situation that should be considered in the choice of the surgical approach. The posterior approach alone may be a good option in the absence of vascular damage. However, due to risk of vessel rupture during the fracture reduction, vascular surgeons must take part in the surgery.Level of Evidence: 5. Clinical Relevance: The article provides help for surgeons who have to treat severe fractures in the context of ankylosing spondylitis Lumbar Spine
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