1 We studied the effects of adding felodipine to W3-adrenoceptor blockade on haemodynamics and exercise capacity in 14 patients with stable angina pectoris using a placebo controlled double-blind crossover protocol. 2 Felodipine reduced supine and standing systolic pressure by 13% (P < 0.01) and 14% (P < 0.01) respectively and increased supine heart rate 7.4% (P < 0.05). 3 Felodipine at a plasma concentration of 15.5 ± 3.0 nmol 1-1 increased exercise duration by 16% (P < 0.01) but failed to attenuate the degree of ST segment depression during exercise. 4 The mean daily number of episodes of angina (0.53 ± 0.16 on placebo vs 0.37 ± 0.11 on felodipine) and mean daily GTN consumption (0.51 ± 0.07 on placebo vs 0.36 ± 0.12 on felodipine) were not significantly reduced (0.1 < P > 0.05). 5 These findings suggest that felodipine may provide useful additional benefits in patients with hypertension or angina pectoris, who are already receiving ,3-adrenoceptor blockers.
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