Effects of felodipine on haemodynamics and exercise capacity in patients with angina pectoris.

Sheridan, J. V.; Thomas, P. C.; Routledge, PA; Sheridan, Desmond J.

doi:10.1111/j.1365-2125.1987.tb03067.x

Cited by 16 publications

(8 citation statements)

References 13 publications

(17 reference statements)

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“…A modest antianginal effect of felodipine was demonstrated in several clinical studies in patients with coronary artery disease during rest [19] and exercise [17][18][19]. The present study may provide the underlying mechanism of this antianginal effect, suggesting that felodipine could exert its beneficial effects by preventing alpha.,-adrenoceptor-mediated coronary vasoconstriction.…”

Section: Hemodgnamic Effects Of T'elodipinementioning

confidence: 69%

“…A modest beneficial action of felodipine in exerciseinduced myocardial ischemia was demonstrated in recent clinical studies [17][18][19]. To elucidate the potential underlying mechanism, the present study was performed to investigate the effect of felodipine on coronary resistance and myocardial function during alpha.~-adrenoceptor activation in the presence of a severe coronary stenosis.…”

mentioning

confidence: 96%

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Felodipine prevents the poststenotic myocardial ischemia induced by alpha2-adrenergic coronary constriction

Ehring

Heusch

1990

Cardiovasc Drug Ther

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Alpha 2-adrenoceptor-mediated coronary constriction contributes to the precipitation of myocardial ischemia during sympathetic activation. Felodipine is a novel dihydropyridine calcium-channel antagonist with vascular selectivity. In this study, the effect of felodipine on alpha 2-adrenoceptor-mediated poststenotic coronary constriction was investigated. In ten open-chest dogs, the selective alpha 2-adrenoceptor agonist BHT 933 (200 micrograms IC) was infused before and after production of a severe stenosis on the left circumflex coronary artery. BHT 933 increased calculated resistance of the intact left circumflex coronary artery from 1.16 +/- 0.30 (SD) to 2.00 +/- 0.70 mmHg*min*100 g/ml (p less than 0.05) without changing posterior systolic wall thickening (sonomicrometry) (14.2 +/- 2.8% vs. 14.1 +/- 2.7%). In the presence of a severe stenosis, BHT 933 increased poststenotic coronary resistance from 1.59 +/- 0.54 to 2.88 +/- 1.16 mmHg*min*100 g/ml (p less than 0.05) and decreased posterior systolic wall thickening from 11.9 +/- 2.7% to 8.2 +/- 3.1% (p less than 0.05). In contrast, after intravenous pretreatment with felodipine (4 micrograms/kg), intracoronary infusion of BHT 933 did not change coronary resistance (1.69 +/- 0.61 vs. 1.61 +/- 0.64 mmHg*min*100 g/ml) and posterior systolic wall thickening (12.1 +/- 3.0% vs. 12.6 +/- 2.9%). In conclusion, felodipine prevents alpha 2-adrenoceptor-mediated coronary constriction and ischemic regional myocardial dysfunction distal to a severe coronary stenosis.

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Section: Hemodgnamic Effects Of T'elodipinementioning

confidence: 69%

mentioning

confidence: 96%

Felodipine prevents the poststenotic myocardial ischemia induced by alpha2-adrenergic coronary constriction

Ehring

Heusch

1990

Cardiovasc Drug Ther

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“…Detry et al reported an increase in exercise capacity after a single dose of felodipine [5]. Sheridan et al confirmed the increase in exercise capacity after 3 weeks' treatment with felodipine 5 mg b. i. d. in addition to a beta-blocker and GTN [7]. Metcalfe et al also employing felodipine as monotherapy confirmed in a longer term study that a modest increase in exercise capacity can be achieved [8].…”

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confidence: 74%

The effects of felodipine in angina pectoris

Lorimer

Macfarlane

Pringle

et al. 1990

Eur J Clin Pharmacol

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Summary.The clinical response to felodipine, in addition to a beta-blocker, was evaluated and compared with placebo in this double-blind cross-over study. Twenty patients with exertional angina pectoris completed the study. Felodipine reduced the number of angina attacks and the Glyceryl Trinitrate (GTN) consumption. The median exercise capacity was increased 33% after 4 weeks' felodipine treatment compared with placebo. At maximal exercise, systolic blood pressure and rate pressure product were reduced by felodipine while no change was seen in heart rate or ST-depression.Felodipine reduced both supine and erect blood pressure. The mean supine blood pressure at rest was 138/82 mmHg after four weeks' placebo treatment compared with 114/71 mmHg after felodipine 5-10 mg b. i. d.Felodipine has overall a modest but significant antianginal benefit when combined with a beta-blocker.

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“…Felodipine is a calcium antagonist with marked vasodilating properties that has been studied in different clinical conditions such as hypertension ]1-4], angina pectoris [5][6][7], and heart failure [8][9][10]. Its vascular selectivity makes it also useful in patients with severe impairment of myocardial contractility.…”

Section: Abstract Felodipine Congestive Heart Failure Regional Blmentioning

confidence: 99%

Felodipine in severe chronic congestive heart failure: Acute effects on central hemodynamics and regional blood flow distribution

Binetti

Rubino

Varani

et al. 1989

Cardiovasc Drug Ther

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In order to assess the effect of felodipine, a new calcium antagonist with vascular selectivity, on regional blood flow distribution at rest in chronic congestive heart failure, ten patients were studied during an acute test. Right heart catheterization allowed the evaluation of hemodynamic parameters; renal blood flow was calculated using paraamino-hippuric acid clearance; hepatic blood flow measurement was based on indocyanine green clearance; and limb blood flow was assessed with venous occlusion plethysmography. Blood samples were collected for the analysis of plasma catecholamines, renin, and aldosterone. All parameters were recorded in duplicate under basal conditions and after felodipine infusion. The infusion of felodipine induced a significant increase in cardiac index, stroke work index, and limb blood flow. Systemic and pulmonary arterial blood pressure, pulmonary wedge pressure, and systemic resistance underwent a significant decrease. The heart rate, pulmonary resistance, renal blood flow, and hepatic blood flow were not changed. In conclusion, felodipine was of benefit in congestive heart failure at rest in an acute test, acting through a marked decrease in vascular resistance and a consequent improvement in cardiac output and limb blood flow. No changes in renal and hepatic blood flow were observed.

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Effects of felodipine on haemodynamics and exercise capacity in patients with angina pectoris.

Cited by 16 publications

References 13 publications

Felodipine prevents the poststenotic myocardial ischemia induced by alpha2-adrenergic coronary constriction

Felodipine prevents the poststenotic myocardial ischemia induced by alpha2-adrenergic coronary constriction

The effects of felodipine in angina pectoris

Felodipine in severe chronic congestive heart failure: Acute effects on central hemodynamics and regional blood flow distribution

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