Summary
A chronic degenerative neurological disorder is described which is characterized by tics, grimacing, involuntary movements, a severe disturbance of swallowing and a concurrent malformation of the erythrocytes. This condition is clearly different from familial hypo-betalipoproteinaemia and abetalipoproteinaemia, the two previously described neurological disorders associated with abnormal red cells.
Summary
A reduction in net surfare charge of approximately 50–60% has been shown by electrophoretic studies on the two examples of red cells possessing Tn polyagglutinability. Also, both cells exhibited enhancement of Rh antigen reactivity and were agglutinated in saline suspension by incomplete anti‐Rh sera. The polyagglutinable population increased from 30–65% during a four‐month period in one patient, suggesting that this condition was acquired and progressive.
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