During the past few years an automated method for the determination of the concentration of anti-D using the AutoAnalyzer has been used by several workers (Rosenfield, Szymanski, Haber, and Kochwa, 1965; Rosenfield and Haber, 1966;Taswell and Grina, 1968;Moore, 1969;Sturgeon and Kaye, 1970;and Judd and Jenkins, 1970
Summary. A case of atypical polyagglutinability due to the Tn antigen is described. The patient, although apparently healthy, has leucopenia and thrombocytopenia. Her cells presented the usual difficulties of polyagglutinable cells due to the presence of anti‐Tn in typing reagents whether of human or animal origin. The practical advantages, particularly in ABO typing, of using papain to destroy the T and Tn receptors has been demonstrated. Anti‐Tn, like anti‐T, is a 19S and probably a γM globulin.
It has been clearly shown that Tn cells differ from T‐activated polyagglutinable cells and Cad positive cells, but it has not been possible to convert normal cells to Tn cells. Certain aspects of both typical and atypical polyagglutinability have been discussed.
The relation between maternal anti-D concentrations, measured against the British working standard, and outcome of rhesus-sensitised pregnancies was studied.There is a clear relation between increasing anti-D concentrations and the chance of a severely affected baby. Of those pregnancies (78) where serial anti-D concentrations remained below 4 IUI/ml, no baby had a cord haemoglobin below 10 g/dl and three had exchange transfusions. In contrast, of those mothers (106) with anti-D concentrations above 4 IU/ml, 23 had babies with a cord haemoglobin below 10 g/dl and 79 babies had exchange transfusions. It is suggested that those pregnancies where anti-D concentrations remain below 4 IUT/ml represent a relatively safe group in which amniocentesis may be avoided.
The relation between maternal anti-D concentrations, measured against the British working standard, and outcome of rhesus-sensitised pregnancies was studied.There is a clear relation between increasing anti-D concentrations and the chance of a severely affected baby. Of those pregnancies (78) where serial anti-D concentrations remained below 4 IUI/ml, no baby had a cord haemoglobin below 10 g/dl and three had exchange transfusions. In contrast, of those mothers (106) with anti-D concentrations above 4 IU/ml, 23 had babies with a cord haemoglobin below 10 g/dl and 79 babies had exchange transfusions. It is suggested that those pregnancies where anti-D concentrations remain below 4 IUT/ml represent a relatively safe group in which amniocentesis may be avoided.
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