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Gastric secretory function was studied for 24 h in rats bearing permanent gastric fistulas and permanent intravenous cannulas. Rats were oophorectomized and treated for five months with testosterone or estrone, prior to gastric function studies. Gastric juice was collected for 24 h during the infusion of saline or histamine, and then gastric examined for the presence of peptic ulcers. All androgen-treated rats had peptic ulcers at the end of 24 h histamine infusion. Only 14% of estrone-treated rats had these lesions, under similar stimulation. All ulcers were localized in glandular mucosa. No ulcers were found in oophorectomized, untreated controls, infused with histamine. Volume, HCl and pepsin output were not affected by hormonal treatment. Androgen enhanced the susceptibüity of gastric mucosa to the peptic action of gastric juice. However, the study of gastric function did not explain this ulcerogenic effect of male sex hormone.

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