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The relation between blood levels and urinary excretion of amphetamine under controlled acidic and under fluctuating urinary pH values using [ 14C]amphetamine

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N‐2‐Cyanoethylamphetamine in man was metabolized rapidly and extensively, as indicated by the analysis of the drug and its metabolite in urine, under acidic and normal conditions. A comparison with the excretion and metabolism of ethylamphetamine under comparable conditions was made. The results were assessed using an analogue computer; a simple one compartmental model sufficed to describe the excretion and metabolism of ethylamphetamine and amphetamine but the additional programming of free amphetamine was necessary for cyanoethylamphetamine because of its very rapid metabolism to amphetamine.

No abstract