The presentation of two cases of veno-occlusive priapism, in patients of 36 and 58 years, in whom the different medical and surgical techniques employed, failed. The suspicion that high-flow priapism had been provoked by said surgical intervention was confirmed by bilateral arteriographs of the pudendal artery. The treatment, selective embolisation of the affected cavernosal artery with reabsorbable material, led to a rapid return of penile detumescence.
The various components required for individualising clinical drug dosage regimens are reviewed, including a study of 3 types of fitting procedures, 2 types of gentamicin pharmacokinetic model and the utility of D-optimal times for obtaining serum gentamicin concentrations. The combination of the current Bayesian fitting procedure, the kslope pharmacokinetic model [in which the elimination rate constant (kel) can change from dose to dose with changing creatinine clearance] and the explicit measurement of the assay error pattern yielded predictions of future serum gentamicin concentrations which were (a) slightly better than those found using weighted nonlinear least squares; (b) somewhat better than those found with Bayesian fitting and a fixed-kel model; (c) better than those found using the traditional linear regression fitting procedure and a fixed kel model. D-Optimally timed pairs of concentrations also predicted future concentrations at least as well, and more cost effectively.
In women previously irradiated for Hodgkin's disease, ELIOT could avoid repeat irradiation of the whole breast, thereby permitting conservative surgical treatment.
Despite the importance of randomized trials for well-informed decisions in health care, a large proportion of the results of these trials are not published, especially when they are negative. Publication bias has a negative impact in the treatment of patients, due to the distorted impression it leads to for new therapies. Clinical Trial Registries help to overcome this by providing transparency in the process of conducting research. The World Health Organization takes the position that the registration of interventional trials is a scientific, ethical and moral responsibility. Taking account of this global movement, the National Coordinating Centre of Clinical Trials and the Cuban Health Network, designed and implemented the Cuban Public Registry of Clinical Trials. The Registry was established in June 2007 and is intended for public service in Cuban territory, although it is open to registrants and patients outside Cuba. The Registry staff developed a strategy to become a Primary Registry of the World Health Organization, and this was achieved in February 2011.
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