Breast conservative surgery after neoadjuvant chemotherapy in breast cancer patients: Comparison of two tumor localization methods

Espinosa-Bravo, Martín; Avilés, Augusto Sao; Esgueva, Antonio; Córdoba, Octavi; Rodríguez, J.; Cortadellas, T.; Mendoza, C.; Salvador, Rafael; Xercavins, Jordi; Rubio, Isabel T.

doi:10.1016/j.ejso.2011.08.136

Cited by 21 publications

(7 citation statements)

References 28 publications

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“…In this scenario, a radiopaque marker is inserted, usually via ultrasound guidance, around the tumour prior to delivery of therapy which can then be located by the surgeon to allow adequate excision of tumour and/or reconstruction of the breast [ 72 ]. Some studies have shown that in 47% of cases, the radiopaque markers are the only remaining evidence of the original site of tumour [ 73 ]. While these radiopaque markers inserted pre-chemotherapy is helpful for the surgeon, clips should still be placed by the surgeon at the time of surgery to assist the radiation oncologist in delineating the surgical margins of the resected tumour bed.…”

Section: The Role Of Radiotherapymentioning

confidence: 99%

Breast Radiotherapy after Oncoplastic Surgery—A Multidisciplinary Approach

Metz

Snook

Sood

et al. 2022

Cancers

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Oncoplastic breast surgery encompasses a range of techniques used to provide equitable oncological outcomes compared with standard breast surgery while, simultaneously, prioritizing aesthetic outcomes. While the outcomes of oncoplastic breast surgery are promising, it can add an extra complexity to the treatment paradigm of breast cancer and impact on decision-making surrounding adjuvant therapies, like chemotherapy and radiotherapy. As such, early discussions at the multidisciplinary team meeting with surgeons, medical oncologists, and radiation oncologists present, should be encouraged to facilitate best patient care.

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Section: The Role Of Radiotherapymentioning

confidence: 99%

Breast Radiotherapy after Oncoplastic Surgery—A Multidisciplinary Approach

Metz

Snook

Sood

et al. 2022

Cancers

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“…До времени ее широкого внедрения опреде-ление локализации зоны опухоли с помощью маркеров, которые могут точно установить области, подлежащие резекции, остается оптимальным для хирургии МЖ. Ме-тоды локализации основаны на введении радиоактивных частиц Nanocolloid, содержащих жидкости, диффунди-рующие в ткани молочной железы, тем самым ограничи-вая объем прецизионной резекции, особенно при муль-тифокальном заболевании [45] (Espinosa-Bravo M, 2011). Последние нельзя проследить, что требует вторичной ло-кализации с проводником.…”

Section: лечениеunclassified

Проблемы Диагностики И Лечения Первично Операбельного Рака Молочной Железы

Трошенков¹,

Костин²

2015

ИПМ

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“…So far, several pre-NAST marking techniques have been described in the literature: tattoos on the skin in the projection of the tumor tissue [2,3] placement of radiopaque clip in the center of the tumor [1,[4][5][6][7], tumor marking with radioactive seed [8][9][10][11][12], ROLL [12,13], silver wire around the tumor (bracketing) [14,15], radiopaque coil insertion [16], hydrogel markers [17], radiofrequency tag [18].…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Three-Dimensional Breast Tumor Positioning Before Neoadjuvant Systemic Therapy as Promissing Alternative to the Invasive Tumor Marking – Technique Description and Feasibility

Bjelica,

Colakovic,

Opric

et al. 2024

Preprint

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Background: Surgical excision of the lodge of the tumor that has completely clinically regressed after neoadjuvant systemic therapy (NAST) is a necessary part of the treatment of early breast cancer. However, it is significantly hampered by the lack of a spatial landmark concerning the location of the pre-existing tumor in the breast. Standard surgical techniques of targeted excision of the pre-existing tumor bed generally rely on invasive insertion of various markers into or around the tumor before starting NAST. Invasive marking techniques are burdened by the disadvantages of technical complexity, invasiveness of procedures, and insufficient precision. Methods: In this paper authors present an original technique of non-invasive determining of the tumor position in the breast in three dimensions before starting NAST, with intention to overcome the disadvantages of invasive tumor marking. Tumor positioning is performed by ultrasound measurements – detailed description of the technique is given in the main text. The feasibility and precision of the technique was tested by the histological parameters of the adequacy and rationality of excision of the tumor bed, after complete clinical regression of the tumor after NAST, on a pilot series of patients. Results: A pilot series of 33 patients underwent a non-invasive breast tumor positioning technique before starting NAST. Twelve patients with complete clinical regression after NAST have been operated using a non-invasive tumor positioning technique, so far. In all cases, histological signs of tumor regression were verified in the specimen of the excised tumor bed. The ratio of the resected specimen volume to the volume of the tumor before NAST was on average 0,91, which is in favor of the rationality of excision and a good aesthetic effect. Conclusion: The initial results of a pilot series of treated patients imply that a non-invasive three-dimensional tumor positioning technique is feasible, with a satisfactory level of oncological safety and aesthetic effects of surgery. Performing a randomised clinical trial comparing this technique with standard techniques of invasive tumor marking is justified.

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Breast conservative surgery after neoadjuvant chemotherapy in breast cancer patients: Comparison of two tumor localization methods

Cited by 21 publications

References 28 publications

Breast Radiotherapy after Oncoplastic Surgery—A Multidisciplinary Approach

Breast Radiotherapy after Oncoplastic Surgery—A Multidisciplinary Approach

Проблемы Диагностики И Лечения Первично Операбельного Рака Молочной Железы

Non-Invasive Three-Dimensional Breast Tumor Positioning Before Neoadjuvant Systemic Therapy as Promissing Alternative to the Invasive Tumor Marking – Technique Description and Feasibility

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