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In a study designed to investigate the effect of naloxone on ethanol-induced performance deficits in man, ethanol (0.75 g/kg) and naloxone (0.4 mg) or saline were administered to 39 volunteers in a double-blind fashion. Psychomotor performance was assessed on a battery of tests (standing steadiness, pursuit rotor, simple and complex reaction times, a speeded number test and the Vienna Determination Apparatus) and blood and breath ethanol concentrations were monitored. Two experiments were performed: in Experiment 1 ethanol was given before naloxone and in Experiment 2 naloxone was administered before ethanol. There were no significant differences in either blood or breath ethanol concentrations at any time between the ethanol + naloxone and ethanol + saline groups in either Experiment 1 or 2. Although ethanol produced a significant decrement on most of the performance measures, naloxone was without effect. There was no suggestion of ethanol impairment being moderated by naloxone, whether it was given before or after ethanol.