Trypanosomosis is a disease that causes great haematological alterations in the infected. Despite the importance of the disease in animals, there is yet scarce trypanocides available for treatment of infected mammals. The present limitation in chemotherapy in trypanosomosis lead to assessment of the usefulness of imidocarb di propionate as an alternative trypanocide. Twenty one pathogen free albino rats were used in the study. They were randomly grouped into 3 of 7 members each. The GPA was uninfected control, GPB was infected with T. brucei brucei and treated with diminazene aceturate and GPC was infected with T. brucei brucei and treated with imidazole dipropionate. By 5 to 6 days post infection, there was a significant decrease in the PCV and Hb concentration values of the infected groups (GPB and GPC) and up to day 7 in GPC. There were haematological improvement in the infected groups by day 8 post infection (day 3 post treatment) on treatment with imidocarb dipropionate and diminazene in GPB and GPC, respectively. The rapid haematological improvements in the groups were attributed to prompt treatment and acuteness of the disease in the rats. It was concluded that T. brucei brucei alters both the PCV and Hb values of infected rats and treatment with imidocarb dipropionate significantly (p<0.05) improved altered haematological values and therefore could serve as an alternative trypanocide.
Diminazene aceturate is a yellow to orange aromatic diamidine compound with both antibacterial and protozoal activities. Diminazene aceturate is one of the most important drugs used in the treatment of trypanosomosis in animals. It is often used in treatment of Babesia and Trypanosoma species in animals. Over the years, consistent use of diminazene aceturate especially at low doses by quacks made provisions for development of resistant strains of trypanosome species and relapses of infection few days post treatment. The present challenge in chemotherapy in trypanosomosis necessitated the search for alternative therapies in both humans and animal patients. This study experimentally demonstrates the efficacy of imidocarb dipropionate in treatment of trypanosomosis. Its administration at the dose of 24 mg kgG 1 subcutaneously for 2 consecutive days had a curative effect on rats with experimental Trypanosoma brucei infection. There was no relapse recorded in the treated group till the last (12th) day of the experiment. The present study threw some light on the potentials of imidazole dipropionate as an alternative therapy in trypanosomosis. It however requires a much detailed research to confirm its potency as a trypanocid.
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