Comparative Haematological Changes in Rats Experimentally Infected with Trypanosoma brucei brucei and Treated with Imidocarb Dipropionate and Diminazene Aceturate

Abstract

Trypanosomosis is a disease that causes great haematological alterations in the infected. Despite the importance of the disease in animals, there is yet scarce trypanocides available for treatment of infected mammals. The present limitation in chemotherapy in trypanosomosis lead to assessment of the usefulness of imidocarb di propionate as an alternative trypanocide. Twenty one pathogen free albino rats were used in the study. They were randomly grouped into 3 of 7 members each. The GPA was uninfected control, GPB was infected with T. brucei brucei and treated with diminazene aceturate and GPC was infected with T. brucei brucei and treated with imidazole dipropionate. By 5 to 6 days post infection, there was a significant decrease in the PCV and Hb concentration values of the infected groups (GPB and GPC) and up to day 7 in GPC. There were haematological improvement in the infected groups by day 8 post infection (day 3 post treatment) on treatment with imidocarb dipropionate and diminazene in GPB and GPC, respectively. The rapid haematological improvements in the groups were attributed to prompt treatment and acuteness of the disease in the rats. It was concluded that T. brucei brucei alters both the PCV and Hb values of infected rats and treatment with imidocarb dipropionate significantly (p<0.05) improved altered haematological values and therefore could serve as an alternative trypanocide.

Trypanosoma brucei brucei induced hypoglycaemia resulted in severe reduction in hexokinase activity in liver, kidney, brain and heart of untreated Trypanosoma brucei brucei infected mice

“…The significant decrease in Pack Cell Volume (PCV) of the infected group signified blood loss or anaemia in the infected groups which is one of the major signs of trypanosomiasis [12]. This agrees with previous studies on Trypanosoma infection [13,14,15]. Many factors might have contributed to the significant decrease in PCV observed in infected groups.…”

Haematological Indices in Trypanosoma Brucei Brucei (Federe Isolate) Infected Nigerian Donkeys (Equus Asinus) Treated with Homidium and Isometamidium Chloride

“…Post treatment results (Groups 3 and 4) showing increase in Hb concentration and PCV close to values obtained for the uninfected control group, indicate that drugs administered have the potential to improve blood components through their trypanocidal activities, and thereby aid the restoration of cellular functions to pre-infection state. Similar observations were made in a study on T. brucei brucei experimental infection in rats (30), whereby PCV, RBC and Hb values which decreased significantly following the infection were reversed by trypanocidal drug treatment. Increased MCV of the red blood cells (macrocytosis) following treatment in the Nigerian donkeys (Equus asinus), indicates presence of a regenerative anaemia which is usually due to increased erythropoiesis in the bone marrow with the resultant release of macrocytic (large) immature red cells into circulation (31).…”

Comparative mild, moderate and severe effects of Trypanosomiasis and Ancylostomiasis on the Haemogram of Local dog breeds

“…Trypanosomiasis causes great haematological alterations in the infected animals [33]. Anaemia is a cardinal feature of trypanosomiasis, in which red blood cells are removed from the circulation by the mononuclear phagocytic system [5].…”