In the food industry, X-ray inspection systems are utilized to ensure packaged food is free from physical contaminants to maintain a high level of food safety for consumers. However, one of the challenges in the food industry is detecting small, low-density contaminants from packaged food. Cadmium zinc telluride (CZT) photon counting detectors (PCDs) can potentially alleviate this problem given its multi-energy bin capabilities, high spatial resolution and ability to eliminate electronic noise, which is superior to the conventional energy integrating detector (EID). However, the image quality from a CZT PCD can be further improved by applying an optimized energy bin weighting scheme that maximizes energy bin images that provide the largest image contrast and lowest image noise. Therefore, in this work, five contaminant materials embedded in an acrylic phantom were imaged using a CZT PCD while the phantom was in constant motion to mimic food products moving on a conveyor belt. Energy bin optimization was performed by applying an image-based weighting scheme and these results showed contrast-to-noise ratio (CNR) improvements ranging between 1.02–1.91 relative to an equivalent EID acquisition.
The technique developed in this study shows promising results and provides an alternative method to invasive biopsy sampling techniques to monitor the accumulation of bone La. To the best of our knowledge, this is the first reported work that seeks to non-invasively measure bone La via in vivo XRF.
Food x-ray inspection systems are designed to detect unwanted physical contaminants in packaged food to maintain a high level of food safety for consumers. Modern day x-ray inspection systems often utilize line scan sensors to detect these physical contaminants but are limited to single or dual energies. However, by using a photon counting detector (PCD), a new generation of food inspection systems capable of acquiring images at more than two energy bins could improve discrimination between low density contaminants. In this work, five type of contaminants were embedded in an acrylic phantom and imaged using a cadmium zinc telluride (CZT) PCD with a pixel pitch of 330 μm. A set of images were acquired while the phantom was stationary, and another set of images were acquired while the phantom was moving to mimic the movement of a conveyor belt. Image quality was assessed by evaluating the contrast-to-noise ratio (CNR) for each set of images. For imaging times larger than 25 ms, the results showed that the moving phantom data set yielded larger CNR values compared to a stationary phantom. While conventional x-ray inspections often utilize line scan sensors, we report that physical contaminant detection is possible with a CZT PCD x-ray imaging system.
Objectives: Lanthanum (La) and gadolinium (Gd) are known to deposit in bone of exposed populations, namely those who are orally administered lanthanum carbonate (LaC, La 2 (CO 3 ) 3 ) or are injected with Gd-based contrast agents, respectively. In this work, bone La and Gd concentrations from the environment and diet were measured using x-ray fluorescence in ten post-mortem human tibiae. As a secondary objective, bone barium (Ba) and iodine concentrations were estimated. Approach: Two calibration lines were produced for La and Gd and the minimum detection limits (MDLs) of the system were determined using a 180° irradiation-detection geometry. Main results: The MDLs of the system were 0.4 µg La g −1 bone mineral and 0.5 µg Gd g −1 bone mineral. The mean concentrations were −0.02 ± 0.1 µg La g −1 bone mineral and 0.1 ± 0.2 µg Gd g −1 bone mineral in tibiae. The average Ba and iodine concentrations estimated from the experimental La calibration line and Monte-Carlo derived sensitivity factors were determined to be 3.4 ± 0.8 µg Ba g −1 bone mineral and −0.5 ± 0.3 µg iodine g −1 bone mineral. Since it was discovered that four donors previously received an iodine-based contrast agent, the mean concentrations in these donors was 27.8 ± 28.4 µg iodine g −1 bone mineral. Significance: The XRF system has determined baseline concentrations of these four heavy metals in trace quantities from natural exposure pathways (with the exception of iodine in four donors). This indicates that the system can measure low levels in ex vivo tibiae samples and can potentially be further developed for in vivo studies involving live subjects who are directly exposed to these metals.
Objectives: Lanthanum (La) retention in bone has been shown to occur in individuals who are orally administered lanthanum carbonate (LaC), a drug to treat hyperphosphatemia. The breakdown of LaC in the gastrointestinal tract into La3+ and carbonate ions results in residual quantities of La being deposited in bone. We previously reported on a non-invasive x-ray fluorescence (XRF) system that was developed to quantify bone La concentrations and applied it to a series of excised cadaver tibiae. However, given interpatient variability in bone shape and size, differential signal attenuation that occurs in bone and tissue, patient movement and overlying tissue thickness at the measurement site, quantifying bone La concentrations during in vivo measurements in live subjects needs to be investigated further along with the radiation dose associated with the measurement. Approach: Coherent normalization was investigated as a function of overlying tissue thickness, source-subject distance and bone radius through Monte Carlo simulation and experimental work. This was accomplished by observing the ratio of the net La K x-ray peak area to the coherently scattered peak area at 59.5 keV. In addition, the dose delivered during a 2000 s measurement was determined using radiochromic film. Main results: The coherent normalization of the La x-ray signal was shown to be independent of overlying tissue thickness, source-subject movement and bone radius, which indicates that this normalization procedure can correct for these factors. The equivalent skin dose and effective dose were 18.0 mSv and 3.2 μSv, respectively for a five-year-old. Significance: While coherent normalization for the bone lead (Pb) and bone gadolinium (Gd) systems has been shown to be successful, we also report that this normalization procedure can correct for these interpatient variabilities in the in vivo 241Am-La K XRF system.
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