A study of seven pig families enabled the identification of individuals who were homozygous for the gene products identified by the mixed lymphocyte reaction. Homozygotes were engaged as markers to elucidate histocompatibility phenotypes. Thus a system evolved in which histocompatibility phenotypes were assessed independently of serologically dependent techniques.
Ninety Merino weaner sheep were assigned to one of six groups on the basis of liveweight and liver copper concentrations. Sheep in four groups each received one oral dose of oxidized copper wire particles, viz. 2.5, 5, 10 or 20 g per animal. Sheep in another group each received a subcutaneous injection of 12 mg copper as diethylamino cupro-oxyquinoline sulfonate and another group of sheep did not receive any copper supplement. Liver copper concentrations responded positively to copper oxide load. The 2.5 g dose of copper oxide wire was more efficacious than the commercial injectable product in raising copper status, but the higher doses of oxide raised liver copper concentrations to values similar to those recorded in cases of copper poisoning. Copper concentrations in blood plasma, muscle and kidney were not altered by the copper load. No clinical signs, nor biochemical or histological evidence of acute copper toxicity, were found. Liver copper values fell in all sheep from 10 weeks after copper therapy until the end of the trial at 50 weeks post-therapy. Over this period of 40 weeks, the rate of mobilization of liver copper was linear and was positively related to the initial concentration of copper in the liver. A significant proportion of the oxidized copper wire dosed to sheep was recovered in the forestomachs and abomasa of selected sheep 4 weeks after dosing. No evidence of abomasal damage due to particles could be established. It is concluded that oral dosing of oxidized copper wire is a safe and effective method of copper supplementation to sheep.
A simple model of Boussinesq magnetoconvection between boundaries at which Biot-type boundary conditions are applied to the temperature and the magnetic field is considered. It is found that when the magnetic field is strong the thermal boundary condition has little effect, but that for sufficiently weak fields the marginal mode of convection between boundaries at which the flux is fixed takes the form of infinitely wide cells. At higher values of the field strength, provided that the magnetic dilTusivity is low enough, the marginal mode can be oscillatory, but steady convection is found to be rather more common than in the related problem considered by Chandrasekhar (1961), where the magnetic stresses are assumed to vanish at the boundaries of the convecting layer; steady convection is favoured when the layer is a poorer electrical conductor than the material which lies outside it.
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