Riga-Fede disease (RFD) was initially described as a benign ulceration of the lingual frenum or tongue of infants, most commonly resulting from repetitive trauma by natal teeth. However, similar clinical manifestations can also be found in children with repetitive tongue-thrusting habits or certain neurological disorders. This report describes an unusual case of RFD in a 6-year-old Chinese boy. The lesion appeared as an ulcer on the anterior ventral surface of the child's tongue, and was caused by a repetitive tongue-thrusting habit. After eliminating the source of repetitive trauma and starting concurrent use of therapeutic drugs for 1 week, the lesion healed completely.
Purpose:
To investigate the performance of qualitative, quantitative assessment and radiomics models between solitary fibrous tumors (SFTs) and atypical meningiomas (ATMs), and the relationship between imaging parameters and collagen volume fraction (CVF).
Methods:
This study included 132 patients with ATMs and 50 patients with SFTs who underwent MRI. Qualitative assessment was performed using a five-point-scale visual scoring on T1WI and T2WI. Quantitative assessment was conducted by dividing the signal values of tumors by those of centrum semioval or thalamus. Radiomics models were established on T1WI, T2WI, and T1&T2WI. Spearman correlation was used to determine the correlation between CVF and imaging features.
Results
The AUCs and cutoff values of qualitative parameters were 0.913, > 3 on T1WI, and 0.763, ≤ 4 on T2WI in testing set. The AUCs were 0.854, 0.877, 0.942 for T1WI, T2WI and T1&T2WI models in testing set. There were significant differences between radiomics models and qualitative and quantitative assessment in training set (P < 0.05), while there were no significant differences in testing set. Among SFTs, negative correlation was obtained between CVF and qualitative and quantitative parameters on T1WI and T2WI.
Conclusion
The hyperintensity on T1WI and hypointensity on T2WI were valuable for discriminating SFTs and ATMs. The performance of radiomics models was superior to qualitative and quantitative parameters. The imaging parameters on T1WI and T2WI were negatively correlated with CVF among SFTs.
was (11%, 20/181) vs. (6.6%, 28/426), p¼ 0.066. Median age was 70 years (range 48-90). Patients presented with advanced (80%) and locally advanced disease (16%). There were 21 women, 30 light smokers (<1pack/day), 18 heavy smokers (>1pack/day) and 4 never smokers. Most patients had adenocarcinoma histology (82.7%), while 15.4% displayed squamous cell carcinoma. Most common co-occurring mutations were KRAS (36/52), TP53 (23/52), and STK11 (17/52). Of twenty-one patients with available PDL1 testing, the majority were PDL1 negative (16/21), and a positive PDL1 expression >1% was seen in 5 patients. There were 12 patients with intermediate and 8 patients with high tumor mutation burden. Median PFS for patients treated with platinum-based chemotherapy (n¼21), chemoimmunotherapy (n¼8) and immunotherapy (n¼4) was 4.6, 2.9 and 2.0 months, respectively. Median OS for patients with KEAP1/NRF2 mutations was 16.6 months for all patients. Median OS was 20 months for Hispanics and 15.4 months for NHWs. (p¼0.99). Conclusion: KEAP1/NRF2 mutations portend poor prognosis and treatment resistance for both Hispanics and NHWs in this cohort. There was no statistical difference in prevalence of KEAP/NRF2 mutations and median overall survival for Hispanics when compared to NHWs with KEAP1/NRF2 mutations.
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