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The results of this study demonstrate that the insulin/DCK formulation can be absorbed in the intestine and that it is biologically efficacious. We therefore suggest that this oral formulation could be used as an alternative to injectable insulin with enhanced clinical effects.

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Single-shot nanometer-scale imaging techniques have become important because of their potential application in observing the structural dynamics of nanomaterials. We report here the image reconstruction results obtained using single-shot Fourier transform x-ray holography with an x-ray laser driven by a table top laser system. A minimum resolution of 87 nm was obtained from the reconstructed image. We could also discriminate the aggregates of carbon nanotubes, which shows the feasibility of single-exposure nanoimaging for real specimens using a laser-driven x-ray laser.

We report the manufacturing of an (ultra-)thin foil target made of conjugated polymer, poly(9,9′-dioctylfluorene-co-benzothiadiazole) (F8BT), and the simultaneous observation of laser-accelerated ions and second harmonic radiation, when irradiated with ultrahigh-contrast laser pulse at a maximum intensity of 4 × 1019 W/cm2. Maximum proton energy of 8 MeV is achieved along the target normal direction. Strong second harmonic with over 6% energy ratio compared to fundamental is emitted along the specular direction. Two-dimensional particle-in-cell simulations confirm the simultaneous generation of protons and high-order harmonics, which demonstrates the feasibility of applications requiring particle and radiation sources at once, effectively using the same laser and target.

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A variant of a grazing-incidence pumping ͑GRIP͒ scheme for Ni-like x-ray lasers using a single shaped pulse from a 10-Hz Ti:sapphire laser system has been demonstrated. Experimental and numerical results show that efficient excitation leading to the lasing process can be achieved by controlled shaping of the pump laser pulse. Such a pulse has been defined for a silver slab target. A gain coefficient as high as 76 cm −1 was estimated. Results indicate that the nanosecond amplified spontaneous emission background of the leading edge of the driving pulse is decisive for an efficient pumping process in this version of GRIP.