No abstract

Administration of haloperidol, a common neuroleptic, to pregnant or lactating rats impaired the masculine sex behavior of their male offspring. Prenatal haloperidol did not affect testosterone concentrations in fetuses. Maternal administration of apomorphine, a dopamine agonist, and of alpha-methyl-p-tyrosine, an inhibitor of dopamine synthesis, also demasculinized male offspring. In both experiments other behaviors and developmental milestones were unaffected. Perinatal haloperidol, apomorphine, and alpha-methyl-p-tyrosine did not lower testosterone in adulthood. These drugs may act directly on neurons that control masculine behavior without lowering testosterone prenatally or in adulthood.

No abstract

Hypothermia and other persisting disturbances in thermoregulation among weight‐recovered anorexia nervosa patients are reviewed. Possible neurobiological mechanisms that might explain these clinical features are presented along with evidence supporting the hypothesis that an increase in nonshivering thermogenesis and an underlying autonomic nervous system imbalance may contribute to the persistence of certain abnormal thermo‐regulatory responses to cold in anorectics.