Cerebral atrophy in bulimia

Hoffman, Graham W.; Ellinwood, Everett H.; Rockwell, W. J. Kenneth; Herfkens, Robert J.; Nishita, J. Ken; Guthrie, Linda F.

doi:10.1016/0006-3223(89)90269-2

Cited by 38 publications

(21 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Previous structural MRI studies of individuals with BN are sparse, with mixed results. Early studies suggest increased cerebrospinal fluid (CSF) in BN compared to control participants, 33, 34 perhaps pointing to widespread reductions in grey and/or white matter volumes. More recent findings show enlarged medial orbital frontal cortex in adults with BN, 6, 35 although other studies report no alterations in grey matter volume in acutely ill (local volumes 36 ) or remitted patients with BN (total volume 37 ).…”

Section: Discussionmentioning

confidence: 99%

Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up

Cyr

Kopala‐Sibley

Lee

et al. 2017

Journal of the American Academy of Child & Adolescent Psych

View full text Add to dashboard Cite

Objective Cross-sectional data suggest functional and anatomical disturbances in inferior and orbital frontal regions in bulimia nervosa (BN). Using longitudinal data, we investigated whether reduced cortical thickness (CT) in these regions arises early and persists over adolescence in BN, independent of symptom remission, and whether CT reductions are markers of BN symptoms. Method Thirty-three adolescent females with BN symptoms (BN or other specified feeding or eating disorder) and 28 healthy adolescents participated in this study. Anatomical magnetic resonance imaging and clinical data were acquired at three time points within 2-year intervals over adolescence with 31% average attrition between assessments. Using a region-of-interest approach, we assessed group differences in CT at baseline and over time, and tested whether between- and within-subject variations in CT were associated with the frequency of BN symptoms. Results Reduced CT in right inferior frontal gyrus persisted over adolescence in BN compared to healthy adolescents, even in those who achieved full or partial remission. Within the BN group, between-subject variations in CT in inferior and orbital frontal regions were inversely associated with specific BN symptoms, suggesting, on average over time, greater CT reductions in those with more frequent BN symptoms. Conclusion Reduced CT in inferior frontal regions may contribute to illness persistence into adulthood. Reductions in the thickness of inferior and orbital frontal regions may be markers of specific BN symptoms. Since our sample size precluded correcting for multiple comparisons, these findings should be replicated in a larger sample. Future study of functional changes in associated fronto-striatal circuits could identify potential circuit-based intervention targets.

show abstract

Section: Discussionmentioning

confidence: 99%

Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up

Cyr

Kopala‐Sibley

Lee

et al. 2017

Journal of the American Academy of Child & Adolescent Psych

View full text Add to dashboard Cite

show abstract

“…Similarly, MRI studies in AN showed larger CSF volumes in association with deficits in both total grey matter (GM) and total white matter (WM) volumes (108) as well as enlarged ventricles (109)(110)(111). Fewer neuroimaging studies have been conducted in BN, and those have found decreased cortical mass (112)(113)(114). Whether these abnormalities persist to a lesser degree after weight restoration is less certain, since some studies show persistent alterations (108) but other studies show normalization of grey and white matter after recovery in AN and BN {Wagner, 2006 #2829 As noted above, in order to avoid the confounding effects of malnutrition, extremes of food ingestion and/or weight loss, the review of other imaging studies will focus mostly on studies of individuals after recovery from an ED.…”

Section: Brain Structurementioning

confidence: 99%

Neurobiology of anorexia and bulimia nervosa

Kaye

2008

Physiology & Behavior

519

369

View full text Add to dashboard Cite

“…These include metabolic and en docrine abnormalities [Pirke and Ploog, 1986], but sev eral studies have also demonstrated remarkable morpho logical brain alterations in severely emaciated anorectic patients as well as in normal weight bulimics during the acute stage of illness [Datlof et al, 1986;Krieg et al, 1988Krieg et al, , 1989bHoffman et al, 1989]. In cranial comput erized tomography (CT) the typical abnormalities are an enlargement of the cortical sulci and cistemes and a dila tation of the ventricles.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Atrophy and Vigilance Performance in Patients with Anorexia nervosa and Bulimia nervosa

Laessle

Krieg²,

Fichter³

et al. 1989

Neuropsychobiology

View full text Add to dashboard Cite

The relationship between ventricular size, as a measure of brain atrophy, and performance on a vigilance task was investigated in 39 patients with anorexia or bulimia nervosa during the acute stage of their illness. Compared to normal controls, the patients performed significantly more poorly in the cognitive task. Half of the patients displayed enlarged ventricles. However, the patients with ventricular dilatation did not perform worse in the cognitive test than patients with normally sized ventricles. Other clinical characteristics, such as symptom severity or duration of illness, were also not correlated with ventricular size. These results support the interpretation that cerebral atrophy per se does not have severe consequences on the neuropsychological or psychopathological status in eating disorder patients.

show abstract

Cerebral atrophy in bulimia

Cited by 38 publications

References 16 publications

Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up

Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up

Neurobiology of anorexia and bulimia nervosa

Cerebral Atrophy and Vigilance Performance in Patients with Anorexia nervosa and Bulimia nervosa

Contact Info

Product

Resources

About