There is continuous need for blood components with long shelf life. To this end
the ‘circle’ triple pack has been modified to provide 35-day red cell and 7-day platelet
concentrates, in PVC bags of identical formulation and 0.4 mm thick. The plasticizer is a
mixture of DEHP and TOTM (CLX Mark II). The primary pack contains 63 ml of CP
277.5 mM glucose. The third pack contains 100 ml of citric acid 2 mM, trisodium citrate
20 mM, NaH(2)PO(4) 20 mM, NaCl 123 mM, glucose 40 mM, and adenine 1.26 mM. Plasma is
adenine-free.With these modifications both hard- and soft-spun red cells gave satisfactory
biochemical and autologous survival indices up to 35 days of storage, the haematocrit not
exceeding 60%. Platelet concentrates were acceptable at 7 days of shelf-life.
Platelet concentrates were prepared in plastic packs of polyvinyl chloride with
tri-(2-ethylhexyl) trimellitate as plasticizer. They were stored, with gentle shaking, at room
temperature for periods up to 7 days before labelling with isotope and reinfusing. In vivo
survival studies, platelet counts, pH and electron microscopy indicated that platelet concentrates
prepared in the new plastic were superior to those prepared in the standard pack
currently in use. Oxygen was found to diffuse through the new pack more rapidly than
through the standard pack. A shelf life of up to 1 week at room temperature seems possible for
platelet concentrates prepared in the new plastic.
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