Objective: The objective of this study was to evaluate sustained release matrix tablets of metformin formulated using Detarium microcarpum gum (DMG) as the matrix polymer. Methods: DMG was produced by acetone desolvation of the filtrate obtained by maceration of powdered seeds of Detarium microcarpum in distilled water. Metformin matrix tablets were prepared by direct compression technique using DMG or sodium carboxymethylcellulose (NaCMC) alone, or their combinations as the polymer matrix. The tablets were evaluated for hardness, friability, weight uniformity, drug content, swelling behaviour and in vitro dissolution. They were compared to a marketed product. Results: The results of the evaluation showed that the tablets had physical characteristics that were within the acceptable limits and were comparable to the marketed product. They include hardness (7.13±1.99 to 13.17±1.59 Kgf), friability (0.40 to 0.80%), and drug content (95.11 to 104.17%). Formulations MTF2 (30% DMG) and MTF6 (20% DMG and 10% NaCMC) showed good sustained release behaviour, as they released 75% of the drug within 7 to 9 h and 100% release in more than 12 h. Conclusion: DMG alone or with NaCMC was successfully used to formulate sustained release metformin matrix tablets that were comparable to the marketed product.
Cellulose is an abundant renewable biodegradable polymer regarded as a promising feedstock for chemical productions with its versatility evaluated as a useful structural and functional material for pharmaceutical and industrial applications. It is a straight chain polymer which appears in cell walls of most plant and consists of D. glucose units, with absence of coiling or branching and can be derived from variety of sources including: annual plants, microbes, animals etc. Three basic types of cellulose often exist in nature as - alpha (α), beta (β) and gamma (ϒ). Microcrystalline cellulose (MCC) sourced from cellulose, occurs as a purified and partially depolymerized alpha cellulose from plant parts such as D. arborea stem possibly by severe acid or alkaline hydrolysis. D. arborea plant is a palm – like tree of 1.5m height with several branches, often used as a boundary mark, a non-selective habitat and belongs to the family Asparagaceae, sub family Nolinoideae. With alkali hydrolysis of the D. arborea stem, the percentage yield of MCC from the alpha cellulose is 54.32%. Physicochemical analysis of the MCC reveals it to have a pH of 7.80 and physicotechnical analysis resulted in values as recommended in the official monogragh. Proximate principles of the extracted MCC, depicted percentage fiber content as 65.78% and low lipid and protein content as 0.6 and 0.4% respectively. Elemental analysis shows the composition of sodium and iron as 41% and 35% respectively but absence of lead and other deleterious materials. FTIR analysis suggests the presence of carbonyl groups, 6- membered cyclic ring (aromatic structure) with ortho and meta - OH substitution and long aliphatic chains. The x-ray diffraction study gave a percentage crystalinity index of 6.02 at 2q = 22 and 2q = 34.
Micro crystalline cellulose (MCC) is a major derivative from the bio composite of natural materials such as D. arborea plant stem. It could be useful as a secondary binder and disintegrant in tablet formulation especially following direct compression technique anticipating it to provide high level of disintegration at low use level and utilizing dual mechanisms of wicking and swelling. Tablets of aceclofenac a BCS class II and non steroidal anti inflammatory drug (NSAID) which potently inhibits the cyclo oxygenase enzyme (COX-2) involved in prostaglandin synthesis was formulated by direct compression using MCC from D. arborea stem. Qualitative assessment of the plant extract was carried out and the presence of cellulose confirmed by the appearance of violet – blue coloration while the physicochemical and physicotechnical properties were comparatively evaluated with reference to avicel and corn starch. Three batches of aceclofenac tablets involving Batch A (D. arborea MCC), Batch B (Corn starch) and Batch C (Corn starch and D. arborea MCC in a 1:1 ratio), were implcated in the formulation. Physicochemical study of the MCC reveals a pH of 7.8, mean swelling index 1.14±0.05 ml and hydration capacity of 3.60±0.15 g while the pH of corn starch is 3.90 with swelling and hydration capacity at 5.09±0.03 ml and 8.26±0.01 g respectively. Quality control evaluation of resulting tablet was investigated and the wetting time of batch A tablets was 1.50, batch B 2.30 and batch C 1.80 with percentage moisture content (%) of 60.5, 56.56 and 57.8 and disintegration time (minutes) of 0.22±0.07, 0.35±0.051 and 1.60±0.286 respectively. The drug release profile of batch A, reveals an initial burst release within 10 minutes followed by gradual release while batch C had consistent drug release which was maintained although faster than that of batch A after 10 minutes but batch B had the least drug release rate.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.