A screening was carried out for CVM, BLAD, DUMPS, bovine citrullinaemia, glycogen storage disease V, and Robertsonian translocations in the cattle population of the Czech Republic. In 406 Holstein sires and 146 Czech Pied (Czech Simmental) sires entering the AI programme in the Czech Republic from [2003][2004][2005], no heterozygous sire for DUMPS, bovine citrullinaemia and BLAD was found. The heterozygote was not found also in the beef sires of Charolais, Limousine, Beef Simmental, Blonde d'Aquitaine, Belgian Blue, Aberdeen-Angus, and Hereford breeds. In 111 elite Holstein females, 21 (18.9%) were heterozygotes for CVM, and were dominant homozygotes for BLAD, DUMPS and bovine citrullinaemia. In the myophosphorylase gene responsible for the glycogen storage disease V, in the Charolais (n = 30), Czech Pied (n = 53), and Belgian Blue, Limousine, Blonde d'Aquitaine, Aberdeen Angus, and Beef Simmental sires analysed, the heterozygote was not found. Robertsonian translocations were examined in 767 Holstein sires, 1 010 Czech Pied (Simmental) sires, 142 beef sires, and 48 dams. Of these, 10 sires of Czech Pied breed, 5 beef sires, and 13 females were found to be positive. The monitoring of BLAD, CVM, and Robertsonian translocations is recommended.
ABSTRACT:The aim of the paper was to analyse congenital disorders in the Czech cattle population in 1986-2001. The offspring of 474 sires -215 Czech Simmental, 236 Holstein, and 23 beef -were diagnosed with congenital disorders which were unevenly distributed because only 18 occurred in the progeny of 10 and more sires, in contrast to 88 occurring in the progeny of 1 sire only. Umbilical hernia was the most frequently noted disorder, and 136 sires fathered progeny with limb anomalies. The most frequent gestational accident was schistosomus reflexus, the results suggesting a familial burden. Three sires fathering offspring with the afflicted spinal column and limbs were heterozygous for Complex Vertebral Malformation (CVM) though they had not been reported as such. Foetal defects and stillbirth were quite frequent, and the calves affected were fathered by 56 sires. In rare disorders with a low incidence, an accurate genetic analysis or even simple discrimination between inherited and acquired defects is problematic. It would be our recommendation that those sires with a higher incidence of defects among their offspring should be disqualified from fathering stock bulls, or culled.
Genotyping was carried out for glycogen storage disease type II and type V in seven cattle breeds. The analysis was carried out using the polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) method. In the breeds analysed [Charolais, Czech Spotted (Czech Simmental), Belgian Blue, Limousine, Blonde d'Aquitaine, Aberdeen Angus, and Beef Simmental sires reared in the Czech Republic], the recessive allele was not found in the PYGM (phosphorylase glycogen, muscle) responsible for the glycogen storage disease type V. In the same panel, the recessive allele in exon 7, exon 9 and exon 13 of the GAA (glucosidase alpha, acid), causing the glycogen storage disease type II was not found. Therefore, we have not revealed the recessives outside previous reported breeds. The knowledge of the breed-specific occurrence of inherited disorders facilitates focusing and reduces the costs of detecting the heterozygous carriers of recessive inherited disorders.
The aim of this study was to evaluate frequencies of Robertsonian translocations, aneuploidy, and chimerism in Holstein-Friesian, Czech Simmental, and different beef breeds in the Czech Republic from 1996 to 2007. A total of 2,425 animals were examined: 2,377 males, (991 Holstein-Friesians, 1,218 Czech Simmental sires, 168 sires of beef breeds) and 48 females. Translocation was found in 10 Czech Simmental sires, 2 Highland, 1 Charolais, and 3 Blonde d' Aquitaine sires, and in 13 females. Chimerism (XX/XY) was found in 9 Czech Simmental sires, and in 5 Holstein-Friesian sires; XXX trisomy was found in 2 heifers and XXY trisomy in 3 Charolais sires. We recommend that animals with such anomalies should be disqualified from siring stock bulls.
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