Male rats were given bilateral injections of 6-hydroxy-dopamine hydrochloride (6-OHDA; 12 µg salt dissolved in 0.001 NHC1) into the preoptic area or the medial forebrain bundle. A control group of animals received solvent only. LH concentrations in rats which had received the 6-OHDA were significantly reduced at 2, 3 and 4 h after injection (p < 0.01). No significant differences in LH concentrations were found between the two groups sampled at one or two days after injection (p>0.05). FSH concentrations in all groups were not significantly different (p > 0.05). These results suggest that tonic LH release is modulated by an extra-hypothalamic noradrenergic mechanism.
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