Effects of Intraventricular Injections of 6-Hydroxydopamine on Plasma Lh and FSH in Male Rats

Kitchen, J. H.; Ruf, K. B.; Younglai, Edward V.

doi:10.1530/jrf.0.0400249

Cited by 13 publications

(6 citation statements)

References 14 publications

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“…LH and testosterone. The hypothesis is consistent with reports that decreased noradrenaline stores suppress the secretion of LH [38,39] and of testos terone [39] in adult male rats. This mechanism may be involved in the feedback control of gonadotropin secre tion, since subcutaneous or intrahypothalamic implanta tions of testosterone lead to a reduced turnover of nor adrenaline in the mediobasal hypothalamus as well as decreased plasma LH levels in castrated rats [40], Activa tion of the central cb-adrenergic system by testosterone has been demonstrated [41], Alternatively, cb-adrenoceptors may be negatively cor related with plasma testosterone levels in an indirect manner involving other neurons.…”

Section: Discussionsupporting

confidence: 93%

Correlations between the Hypothalamic Density of <sup>3</sup>H-Clonidine-Binding Sites and Plasma Testosterone Levels in Mice

Шишкина

Науменко

1995

Neuroendocrinology

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Correlations between the specific binding of radiolabelled adrenoligands in frontal cortex and hypothalamus, and plasma testosterone levels were investigated in inbred mouse strains. Binding values were structure and genotype dependent. There were significant negative intrastrain and interstrain correlations between hypothalamic binding of ³H-clonidine, an imidazoline with α₂-adrenoceptor agonist specificity, and resting testosterone levels. Neither binding of the α₁ -adrenoceptor antagonist ³H prazosin nor of the β-adrenoceptor antagonist ³H-dihydroalprenolol (DHA) correlated significantly with hormone concentrations. The inverse correlation between hypothalamic ³H-clohidine-binding and plasma testosterone levels suggests a possible role of α₂-adrenoceptors in the negative regulation of testosterone plasma levels.

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Section: Discussionsupporting

confidence: 93%

Correlations between the Hypothalamic Density of <sup>3</sup>H-Clonidine-Binding Sites and Plasma Testosterone Levels in Mice

Шишкина

Науменко

1995

Neuroendocrinology

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“…As was recently reported, potentiation of LH responses to NA occurs in 6-OHDA-treated rats (Bacha, Donoso, 1974). This supersensitivity may explain the absence of chronic modifications in LH in animals with central adrenergic lesions (Kitchen, 1974;Kitchen, Ruf, Younglai, 1974;Macdonald, Airaksinen, 1974;Donoso, Bishop, McCann, unpublished). 6-hydroxydopamine may cause, however, some early modifications of gonadotrophin release (Kalnins, Ruf, 1971;Kitchen, 1974;HSkfelt, Fuxe, 1974).…”

Section: Discussionsupporting

confidence: 61%

Acetylcholine induced responses of plasma LH and prolactin in normal and 6-hydroxydopamine-treated rats

Donoso¹,

Bacha²

1975

J. Neural Transmission

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The effects of intraventricular injection of acetylcholine at doses of 50 mug were studied in male rats. Under ether anesthesia, acetylcholine did not modify plasma prolactin and LH levels. Contrarily, in rats anesthetized with pentobarbital, acetylcholine at the same doses induced significant decreases of prolactin from 10 to 60 min postinjection. LH levels were not modified by treatment. Prolactin responses to acetylcholine were absent during the first 30 min postinjection in 6-hydroxydopamine-treated rats. Only a delayed response was detected. In these animals, icv administration of dopamine caused a clear decrease of plasma prolactin levels. A marked rise of LH at 30 and 60 min following acetylcholine injection was found in 6-hydroxydopamine-treated rats. Results suggest a catecholaminergic mediation of the prolactin and LH responses induced by acetylcholin in male rats.

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“…Ojeda and McCann (1973) showed that the rise in plasma LH observed 16 h following orchidectomy was prevented by a-MPT injected 2 h after the castration. A low dose of 6-hydroxydopamine injected into the lateral ventricle caused a functional impairment of catecholaminergic neurons, which resulted in a transient decrease of LH (Kitchen et al, 1974) and testosterone level (Vermes et al, 1977, unpublished) in the peripheral blood. Castration altered the activity of tyrosine-hydroxylase, but not the tryptophan-hydroxylase activity of the hypothalamus in male rats (Kizer et al, 1974).…”

Section: Discussionmentioning

confidence: 99%

Effects of Drugs on Brain Neurotransmitter and Pituitary-Testicular Function in Male Rats

Vermes¹,

Tóth²,

Telegdy³

1979

Horm Res

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The effects of different drugs influencing brain neurotransmitter contents have been tested on the pituitary-testicular function in male rats. L-dopa (200 mg/kg body weight, i.p.) increased the dopamine and noradrenaline contents of the hypothalamus, amygdala, striatum and mesencephalon, but it was ineffective as regards the 5-hydroxytryptamine contents of the same brain areas, and increased the plasma testosterone level. α-Methyl-p-tyrosine (250 mg/kg b.w., i.p.) decreased the dopamine and noradrenaline contents of these brain areas, but it was ineffective to 5-hydroxytryptamine, and decreased the plasma testosterone level. Diethyldithiocarbamate (400 mg/kg b.w., i.p. twice a day) increased the dopamine levels in the hypothalamus, amygdala, striatum and mesencephalon, decreased the noradrenaline contents in the same brain regions but had no effect on the 5-hydroxytryptamine contents of these brain areas or on the testosterone level in the peripheral blood. p-Chlorophenylalanine (300 mg/kg b.w., i.p.) decreased the 5-hydroxytryptamine contents of the different brain areas, while it had no effect on the dopamine and noradrenaline levels or on the plasma testosterone level. 5-Hydroxytryρtophan (200 mg/kg b.w., i.p.) increased the 5-hydroxytryρtamine contents of all brain areas studied, but was without effect on the dopamine and noradrenaline contents or the plasma testosterone level. The data suggest that both dopamine and noradrenaline may be involved in the regulation of the pituitary-testicular function, and the ratio of the two transmitters might be more important than their actual levels in definite brain areas.

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Effects of Intraventricular Injections of 6-Hydroxydopamine on Plasma Lh and FSH in Male Rats

Abstract: Summary. The

Cited by 13 publications

References 14 publications

Correlations between the Hypothalamic Density of <sup>3</sup>H-Clonidine-Binding Sites and Plasma Testosterone Levels in Mice

Correlations between the Hypothalamic Density of <sup>3</sup>H-Clonidine-Binding Sites and Plasma Testosterone Levels in Mice

Acetylcholine induced responses of plasma LH and prolactin in normal and 6-hydroxydopamine-treated rats

Effects of Drugs on Brain Neurotransmitter and Pituitary-Testicular Function in Male Rats

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