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We report the status of hybrid scenario experiments in Korea Superconducting Tokamak Advanced Research (KSTAR). The hybrid scenario is defined as stationary discharges with β N ⩾ 2.4 and H 89 ⩾ 2.0 at q 95 < 6.5 without or with very mild sawtooth activities in KSTAR. It is being developed towards reactor-relevant conditions. High performance of β N ≲ 3.0, H 89 ≲ 2.4 and G-factor (≡ β N H 89 /q 2 95 ) ≲ 0.46 has been achieved and sustained for ≳ 40τ E at n e /n GW ~0.7 with heating power of ≲5 MW. Some KSTAR hybrid discharges exhibit a unique feature of a slow transition from conventional H-mode to hybrid mode after the third neutral beam injection. The reason for the confinement enhancement is extensively studied in this transition period of a representative discharge exhibiting a common feature of KSTAR hybrid scenarios. 0D performance analysis with magnetohydrodynamic activities, 1D kinetic profile dynamics, power balance analysis, linear gyro-kinetic analysis and edge pedestal stability analysis were conducted. The enhancement is thought to be from both the core and the pedestal. The improvement in the core region of the ion energy channel is observed from the linear gyro-kinetic analysis considering the electromagnetic, the fast ion, the Shafranov shift, ω E×B , and the magnetic shear effect. The electromagnetic finite β stabilisation plays a role in the inner core region at ρ tor ∼ 0.35 together with the fast ion effect. The alpha stabilisation effect is also found at ρ tor ∼ 0.5. ω E×B , which could reduce the linear growth of the ion temperature gradient mode in the outer core region at ρ tor ∼ 0.5 − 0.7 with the highest contribution from the toroidal rotation. Regarding the improvement in the pedestal, Shafranov shift broadens the stability boundary of the pedestal in support of the diamagnetic effect. The pedestal height and width could be reproduced by the EPED model, while a realistic current profile is used to calculate the internal inductance for Shafranov shift. Based on these findings, a comprehensive confinement enhancement mechanism has been proposed by considering the core-edge interplay.

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A planar coil of multiple loops connected in series and in parallel is proposed for wireless power transfer (WPT). The current direction in each loop is mixed in forward and in reverse. The proposed coil gives uniform mutual inductance and enables simple impedance matching for free-positioning WPT.

Indenone KR-62776 acts as an agonist of PPAR gamma without inducing obesity in animal models and cells. X-ray crystallography reveals that the indenone occupies the binding pocket in a different manner than rosiglitazone. 2-Dimensional gel-electrophoresis showed that the expression of 42 proteins was altered more than 2.0-fold between KR-62776- or rosiglitazone-treated adipocyte cells and control cells. Rosiglitazone down-regulated the expression of ERK1/2 and suppressed the phosphorylation of ERK1/2 in these cells. However, the expression of ERK1/2 was up-regulated in KR-62776-treated cells. Phosphorylated ERK1/2, activated by indenone, affects the localization of PPAR gamma, suggesting a mechanism for indenone-inhibition of adipogenesis in 3T3-L1 preadipocyte cells. The preadipocyte cells are treated with ERK1/2 inhibitor PD98059, a large amount of the cells are converted to adipocyte cells. These results support the conclusion that the localization of PPAR gamma is one of the key factors explaining the biological responses of the ligands.

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