14 patients with amenorrhoea and 11 patients with anovulatory haemorrhages were treated with prednisone.
10 patients showed hirsutism and/or increased 17-ketosteroid excretion indicating a possible adrenocortical dysfunction.
6 of 25 patients developed ovulatory haemorrhages, viz. 4 patients with amenorrhoea and 2 patients with anovulatory bleeding. There was no difference in results between the patients with and those without any signs of a disturbance in the adrenocortical function.
With regard to the condition of the patients it is concluded that prednisone has a therapeutic importance in:
conditions related to congenital adrenocortical hyperplasia, virtually regular anovulatory haemorrhages, normo-oestrogenic amenorrhoea.
Since ovarian wedge resection was primarily performed in the successfully treated 4 patients with amenorrhoea, the question arises as to whether the results should not be attributed to the combination of bilateral wedge resection of the ovaries and prednisone treatment. This question is at present under investigation.
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