SummaryThe addition of 1-20% (v/v) of methanol or acetonitrile as organic modifier to the mobile phase in a micellar electrokinetic capillary chromatographic (MECC) system, containing sodium dodecyl sulfate and a buffer, is shown to extend the elution range and thus increase the peak capacity of a given system. Although thenet changein theelution rangeparameter, tO/tmc,is essentially the same for both modifiers, the acetonitrile-modified system exhibits much faster elution times for the polar and non-polar test solutes employed in this study. Retention, as measured by thecapacity factor, is generally decreased with the increaseof anorganic modifier, just as in conventional reversedphase chromatography. However, changes in selectivity as a function of the added modifiers are noted among polar and nonpolar solutes as well. The efficiency of these MECC systems is increased with the addition of either organic modifier.

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