The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.
Suspensions of the cells of baker’s yeast were irradiated with ultraviolet light for sufficient times to produce populations of 75, 50, 30, and 5% viable cells. After washing and drying, various enzyme solutions were prepared from these cells. Enzymatic activities, on a nitrogen basis, were compared to those of solutions prepared from a nonirradiated population. At the 50% survival level, hexokinase, carboxylase, and zymase were inhibited to a degree roughly proportional to the viability. Carboxylase, and to a certain extent, hexokinase activity varied directly as the population viability. Catalase, alcohol dehydrogenase, and lactic dehydrogenase showed no diminution in activity even at the 5% survival level. These results suggest that although ultraviolet radiation may produce nuclear damage, the primary site of action may be certain enzymes of the cytoplasm.
Several weeks ago I had the privilege of hearing a practitioner of some fifty years' experience lecture to a group of medical students on the art of practicing medicine. His general theme was that despite the great increase in scientific knowledge that had taken place during his lifetime, the doctor‐patient relationship had not diminished in importance. He was not a therapeutic nihilist and neither am I.
DETERMINATION OF COCARBOXYLASE IN BLOOD 605 cyanide to the system, and the use of an internal standard during assay. 3. Plasma showed an activating effect on cocarboxylase. 4. Reference is made to the effects of thiamine and iodoacetate in the system. 5. The possible significance of the sulphydryl form of cocarboxylase in decarboxylation is discussed. We are grateful to Roche Products Ltd. for a timely gift of pure cocarboxylase.
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