SynopsisThe molecular weights and radii of gyration of Streptococcus salivarius levan fractions were obtained from light-scattering measurements iii water. Sedimentation coefficients and partial specific volumes of the fractions were also obtained. Double logarithmic plots of [q] versus and SO versus li?, yielded slopes having values of 0.17 and 0.62, respectively. The data and various calculated parameters show that levan from Streptococcus salivarius is highly branched and behaves hydrodynamically as a compact particle of spherical symmetry.
It has long been known that interaction of blood with artificial surfaces results in thrombogenic effects. With the increased use of prosthetic cardiovascular appliances, it is becoming more evident that surfaces which are thromboresistant are of utmost importance. A review is presented of the recent research on binding of heparin by ionic, covalent and thermal means, to different polymer surfaces, with the results of in vitro and in vivo tests. Additionally, a survey of theories on the role of heparin surfaces in thromboresistance is given.
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