Background: Lorlatinib, also known as PF-6463922, is a third-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor that had been approved clinic treatment with patients who failed previous ALK inhibitors. However, the growth inhibitory effects of Lorlatinib on NSCLC and the underlying mechanism. Method: The growth inhibitory effects of Lorlatinib were investigated in H3122 and H2228 cell lines.
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