In haemophiliacs, the physical condition, muscular strength, aerobic resistance, anaerobic resistance and proprioception have all diminished. Muscle atrophy and instability, being more vulnerable to stressful motor demands, increase the risk of lesion and establish a vicious circle that is hard to break: pain, immobility, atrophy, articular instability and repeated bleeding episodes. In haemophilia, physical and/or sporting activities were not recommended until the seventies. Nowadays, the overall policy is to recommend certain physical activities, especially swimming, to improve the patient's quality of life, thanks to prophylaxis programmes. The objective of this study is to perform a systematic review of the exercise and sporting activities recommended for haemophiliacs. Experimental and observational studies and clinical assays about rehabilitation for haemophiliacs with exercise and sporting activities have been included. The relevant studies were identified in Medline, Cinahl, Embase and SportDiscus, and key words were: haemophilia, exercise and sport (with no language restrictions). Works were independently analysed by reviewers and the following were identified: of 3603 studies, 103 were included in this review: 29 (28.15%) were experimental, 27 (26.21%) were observational and 47 (45.63%) were clinical. Physiotherapy, physical activity and sport are basic elements to improve quality of life and the physical condition, increase strength and resistance and to reduce the risk of musculoskeletal lesions and to prevent haemophilic atrophy. In general, professionals in haemophilia believe that regular exercise and rehabilitation with physiotherapy is fundamental, particularly in countries where replacement therapy is not readily available.
Musculoskeletal disorders in haemophiliacs represent the highest percentage of lesions, giving rise to haemophilic arthropathy (HA) which predominantly affects lower limbs, influencing postural control, standing and walking. Leading a sedentary lifestyle seems to influence strength and muscular resistance in haemophiliacs which, in turn, are related to articular stability and the prevention of articular degenerative processes. The objective of this work was to study alterations in balance to subsequently evaluate the appropriate therapeutics and how this influences the development of arthropathy. Twenty-five haemophiliacs with HA, 25 haemophiliacs without HA (NHA) and 25 healthy control subjects (CTL) took part in this study. Tests were performed on a force platform and the subjects remained as still as possible for 30 s under different conditions: (i) bilateral stance with eyes open; (ii) bilateral stance with eyes closed; (iii) right unilateral stance; and (iv) left unilateral stance. The results of these tests indicated significant differences (P < 0.05) between the groups HA, NHA and CTL. The HA group presented worse results for both unilateral and bilateral stance when compared with the other two cohorts. Surprisingly, the NHA group displayed a worse balance than the controls. A single calculated parameter (mean frequency) did not show significant differences. This apparently indicates the absence of pathology in the nervous system in relation to postural control. The results suggest that our patients should participate in physical exercise programmes, rehabilitation and physiotherapy to improve their postural control.
In the general population, the degenerative processes in joints are directly related to adult age, and osteoarthrosis represents the most frequent musculoskeletal alteration. In the haemophilic patient, the degenerative processes in the joint begin at very early ages, and are directly related to musculoskeletal bleeding episodes, which are occasionally subclinical and constitute haemophilic arthropathy. In the haemophilic patient, arthropathy constitutes the most frequent, severe and disabling pathology, and its assessment includes muscular force-related parameters. We have studied the value of Maximum Isometric Voluntary Contraction in the quadriceps femoris of 46 subjects, 28 haemophiliacs (16 severe, eight moderate and four mild) and 18 healthy individuals with a view to establishing appropriate values of force and to restoring physical therapy recommendations. The maximum force values were significantly greater (P < 0.001) in the healthy individuals group. The mild haemophiliacs group also presented significant differences of force (P < 0.05) in relation to the severe and moderate haemophilic patient groups. The mild and severe haemophilia patients presented greater fluctuations of force (P < 0.001) than the control group, the haemophilia group have a minor skill to produce constant force. The seriousness of the arthropathy in the knee is directly related to diminished values of maximum force. Our work evidences that patients with severe haemophilia present a greater degree of arthropathy in relation to moderate and mild haemophilia patients. Haemophilic arthropathy is associated with muscular atrophy and strength deficit. In haemophilic patients, the deficit of maximum force and the presence of fluctuations may suggest an increased risk of bleeding during physical activities and the need to programme specific physical therapy guidelines which increase muscular power through resistance training.
Thirteen patients with haemophilia A took part in this study voluntarily. They underwent an aquatic training programme over a 9-week period (27 sessions; three sessions per week; 1 h per session). Their motor performance was assessed by the following cardio-respiratory and mechanical variables before and after the training programme: oxygen uptake (VO(2), mL min(-1)), relative oxygen uptake (rel VO(2), mL min(-1).kg(-1)), carbon dioxide (CO(2), mL min(-1)), respiratory quotient (R), heart rate (bpm) and the distance covered in 12 min (the Cooper test, m). Nine patients successfully completed the intervention and measurement protocols without bleeding or other adverse events. After the proposed training programme, significant differences between the pre-test and post-test were observed. Patients' aerobic capacity increased considerably, and their oxygen uptake improved by 51.51% (P < 0.05), while their relative oxygen uptake went up by 37.73% (P < 0.05). Their mechanical capacity also increased considerably (14.68%, P < 0.01). Our results suggest that 27 specially designed aquatic training sessions for our patients with haemophilia A had a positive effect on their motor performance and considerably improved their aerobic and mechanical capacity without causing adverse effects.
Thirty-six adult men were randomly assigned to a remote stimulation group (RS; n = 18) or control group (CTL; n = 18). The RS group unilaterally performed a 10-minute surface electrical stimulation program (frequency 100 Hz, impulse 300 micros, 10 seconds on/10 seconds off) on the rectus femoris of the non-dominant leg. The subjects of the CTL group relaxed for 10 minutes without performing any training. Immediately before and after the surface electrical stimulation program, the isometric strength and the electromyographic (EMG) and mechanomyographic (MMG) response of the dominant leg was measured for all subjects. The dominant leg of the RS group showed a significant increase in the isometric force (5.11%; P < 0.001) and EMG activity of the agonist muscle (4.67%; P < 0.05), whereas a decrease in EMG activity of the antagonist muscles was observed (-10.27%; P < 0.05). The MMG activity did not show any alteration. No significant changes were observed for the CTL group. These results indicate that one unilateral surface electrical stimulation session on the rectus femoris improves the efficiency of the inactive leg. At a practical level, the results open a new way to rehabilitate muscle-skeletal injuries, especially weak members that cannot do any physical work. In this case, the muscle strength (and physical efficiency) can be improved by passive electrostimulation training on the healthy member.
Little is known about the influence of speed endurance workouts on the improvement of pacing strategies in the 800-m running event. This study aims to analyze it, comparing continuous repetitions vs. interval training workouts. Because we hypothesize that pacing is susceptible to expertise, there might be age differences. Nineteen male 800-m runners (age: 21.36 ± 5.26, season best [SB]: 117.14 ± 5.18 seconds) were tested. Athletes were asked to run 1 × 600 m (6r) at 100% (SB) and 2 × 4 (200 m per 30 seconds) per 15 minutes (B8) at 102% (SB), counterbalanced and randomized within 1 week of difference. Pacing strategy (velocity dynamics) was analyzed by means of time differences in 200-m segments (T200), whereas age category was considered a grouping factor (younger than 23 years-senior, n = 10; vs. juvenile-junior, n = 9; 25.29 ± 4.32, 17.00 ± 0.66 years). Blood lactate was registered after 6r, B(8)1, and B(8)2 bouts. Univariate contrast analysis revealed a significant decrease in velocity during 6r (p < 0.001; 9.33% between first and third segment), thus a positive pacing, whatever the age category. B8 shared this final significant impairment (p < 0.001), although it was smaller (5.73% drop for B(8)1; 8.47% for B(8)2), and neither linear nor significant among consecutive T200. B8 also showed significant differences (p < 0.05) in the interaction sampling condition × age category. The T test added blood lactate significant differences (B(8)2: 15.42 ± 1.16, B(8)1: 12.25 ± 2.03 and 6r: 13.58 ± 1.82 mmol·L(-1)). Summarizing, both methods share a positive pacing, confirming to be related to enhancing energy systems and coping final fatigue in the 800 m. Continuous 6r preserves the nature and tempo of the 800 m, although 1 repetition is metabolically limited. Interval B8 allows larger amounts of high intensity running, enhancing neuromuscular benefits jointly with higher lactate productions. Significant age category differences in B8 indicate that pacing capacity may improve with expertise and interval workouts may be appropriate methods to manage it.
Resumen El ejercicio físico y el deporte constituyen uno de los pilares básicos en el tratamiento de la hemofilia. Este trabajo describe un resumen de las características de la hemofilia y, a través de una exhaustiva revisión bibliográfica, se analiza la importancia de la condición física, en relación con la prevención y el tratamiento de las lesiones musculoesqueléticas en el paciente hemofílico.La hemofilia es una enfermedad hematológica hereditaria, con lesiones ortopédicas características. Afecta a individuos varones y presenta un déficit de factores de la coagulación que provoca hemorragias incluso espontáneas (en pacientes graves sin tratamiento). Las lesiones más frecuentes son: hemartrosis, sinovitis, hematomas musculares y artropatía hemofílica. La condición física del paciente hemofílico, instrumentada mediante terapia sustitutiva de factores de la coagulación, es fundamental y requiere fisioterapia, ejercicio físico y deporte.Basándonos en las recomendaciones de los comités de expertos de la Federación Mundial de Hemofilia (WFH) y utilizando las principales bases de datos, mediante estrategias de búsqueda con palabras clave, se obtuvieron 756 referencias, de las que tan sólo 74 superaron los criterios de inclusión.Las publicaciones se agruparon por áreas temáticas, diferenciando artículos de revisión, trabajos observacionales y experiencias clínicas, estudios experimentales y actuaciones intervencionistas sobre parámetros concretos de la condición física.Se concluye con la evidencia de la importancia de la recomendación del ejercicio físico y deporte en la hemofilia, el consenso en su idoneidad para el bienestar físico, psíquico y social de los pacientes, y la necesidad de incrementar los trabajos científicos al respecto. © 2010 Consell Català de l'Esport. Abstract Physical exercise and sports is one of the basic foundations in the treatment of haemophilia. This article gives a brief description of the characteristics of haemophilia, and through an exhaustive literature review, the importance of the physical condition, as regards prevention and treatment of musculoskeletal lesions in the haemophilic patient, is also analysed.Haemophilia is a hereditary haematological disease, characteristic orthopaedic lesions. It affects males and has a deficiency of clotting factors which causes haemorrhages, including spontaneous (in severe patients without treatment). The most common lesions are: haemarthrosis, synovitis, muscle haematomas and haemophilic arthritis. The physical condition of the haemophilic patient, controlled by clotting factor replacement therapy, is fundamental and requires physiotherapy, physical exercise and sport.Based on the recommendations by expert committees of the World Haemophilia Foundation (WFH) and using major data bases and search strategies with key words, 756 references were obtained, of which on 74 passed the inclusion criteria.The publications were grouped by subject area, differentiating review articles, observational studies and clinical experiences, experimental studies and ...
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