Periodontitis results in higher systemic levels of CRP, IL-6, and neutrophils. These elevated inflammatory factors may increase inflammatory activity in atherosclerotic lesions, potentially increasing the risk for cardiac or cerebrovascular events.
Genetic polymorphisms in the TNF-alpha gene at positions -376, -308, -238 and +489 could not be identified as susceptibility or severity factors in periodontitis, irrespective of the smoking status of the patients.
The results of this study suggest that both the Sm and the Rg genotypes of P micros are part of the normal oral microbiota. However, the elevated prevalence of the Sm genotype in periodontitis and the elevated prevalence of the Rg type in periodontitis patients who smoke implies that both types can behave as opportunistic pathogens in destructive periodontal disease.
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InleidingIn het eerdere artikel over de betekenis en werking van richtlijnen werd achtereenvolgens uiteengezet wat de betekenis van een richtlijn is en wat de achterliggende claims zijn vanuit de verschillende paradigma's. Vervolgens werd ingegaan op hoe de werking van een richtlijn kan worden begrepen (Craandijk, 2017
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