Values of the HI, acidity function have been determined for 0-35% hydrochloric acid using a set of amide indicators. T h e indicator pK values agree with those previously obtained in sulfuric acid. T h e HA scale decreases less steeply than Ho in t h e high concentration region, but the difference between the two functions is less marked than in sulfuric acid. The reasons for this are discussed. T h e values of H:i have been combined with available rate and water activity data to obtain information about the mechanism of amide hydrolysis. Eleven sets of rate data, consisting of 64 rate constants obtained under a variety of experimental couditions, give similar hydration parameters for this reaction. T h e temperature dependence of hydration parameters is discussed.
The oximes of some Mannich bases have been rearranged with phosphorus pentachloride in benzene, to yield p-aminopropionanilides. These p-arnino-derivatives, as their methiodides, react easily with aqueous base to yield substituted acrylanilides which can themselves be unambiguously synthesised from acryloyl chloride and the appropriate arylamine. The addition of dimethylamine to the substituted acrylanilides to yield the corresponding substituted p-aminopropionanilides was also achieved. The oximes of aryl vinyl ketones when treated with phosphorus pentachloride in benzene afforded P-chloropropionanilides. These were also prepared by the addition of hydrogen chloride to the appropriate acrylanilide, and by the reaction of P-chloropropionyl chloride with the appropriate arylamine.
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