✓ A case of progressive paraparesis is reported in which the normal spinal cord herniated through a defect in the ventral meninges and dura and became incarcerated in a cavity in the dorsal aspect of the body of T-7. Progress of the paraparesis was arrested by reduction of the hernia.
Sodium alginate is a seaweed-derived fibre that has previously been shown to moderate appetite in models of acute feeding. The mechanisms underlying this effect may include slowed gastric clearance and attenuated uptake from the small intestine. In order to assess whether alginate could be effective as a means of appetite control in free-living adults, sixty-eight males and females (BMI range: 18.50-32.81kg/m 2 ) completed this randomised, controlled two-way crossover intervention to compare the effects of 7 day daily ingestion of a strong-gelling sodium alginate formulation against a control. A sodium alginate with a high guluronate content was chosen because, upon ingestion, it forms a strong gel in the presence of calcium ions. Daily preprandial ingestion of the sodium alginate formulation produced a significant 134.8 kcal (7%) reduction in mean daily energy intake. This reduced energy intake was underwritten by significant reductions in mean daily carbohydrate, sugar, fat, saturated fat and protein intakes. The absence of any significant interaction effects between the main effect of preload type and those of gender, BMI classification and/or timing of preload delivery indicates the efficacy of this treatment for individuals in different settings. These findings suggest a possible role for a strong-gelling sodium alginate formulation in the future management of overweight and obesity.
HighlightsCertain alginates are effective inhibitors of pancreatic lipase.The level of lipase inhibition by alginates is related to the structure of the polymer.High guluronate alginates achieve greater lipase inhibition than high mannuronate.Alginates have the potential to be a well-tolerated obesity treatment.
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