Pharmaceutical applications of magnetic resonance imaging (MRI)

Richardson, J. C.; Bowtell, Richard; Mäder, Karsten; Melia, Colin D.

doi:10.1016/j.addr.2005.01.024

Cited by 196 publications

(106 citation statements)

References 76 publications

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“…Recent advances in biomedical imaging have provided the essential tools for non-invasive and real-time in vivo evaluation for drug delivery [12][13][14][15]. Noninvasive imaging assessment will be more effective in determination of the pharmacokinetics, biodistribution, target deposition and drug delivery efficiency of polymer drug conjugates.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Visualization of in Vivo Drug Delivery of Poly(l-glutamic acid) Using Contrast-Enhanced MRI

Jeong

et al. 2006

Mol. Pharmaceutics

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Biomedical imaging is valuable for non-invasive investigation of in vivo drug delivery with polymer conjugates. It can provide real-time information on pharmacokinetics, biodistribution and drug delivery efficiency of the conjugates. Non-invasive visualization of in vivo drug delivery of polymer conjugates with contrast enhanced magnetic resonance imaging (MRI) was studied with paramagnetically labeled poly(L-glutamic acid) in an animal tumor model. Poly(L-glutamic acid) is a biocompatible and biodegradable drug carrier for diagnostics and therapeutics. Poly(L-glutamic acid)-1,6-hexanediamine-(Gd-DO3A) conjugates with molecular weights of 87, 50 and 28 KDa and narrow molecular weight distributions were prepared and studied in mice bearing MDA-MB-231 human breast cancer xenografts. Contrast enhanced MRI resulted in real-time and three-dimensional visualization of blood circulation, pharmacokinetics, biodistribution and tumor accumulation of the conjugates, and the size effect on these pharmaceutics properties. The conjugate of 28 KDa rapidly cleared from the circulation and had a relatively lower tumor accumulation. The conjugates with higher molecular weights exhibited a more prolonged blood circulation and higher tumor accumulation. The difference between the conjugates of 87 and 50 KDa was not significant. Contrast enhanced MRI is effective for non-invasive real-time visualization of in vivo drug delivery of paramagnetically labeled polymer conjugates.

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Section: Introductionmentioning

confidence: 99%

Noninvasive Visualization of in Vivo Drug Delivery of Poly(l-glutamic acid) Using Contrast-Enhanced MRI

Jeong

et al. 2006

Mol. Pharmaceutics

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“…exposure that can provide cross-sectional images from inside the solid materials and living organisms (Kim et al, 2003, Richardson et al, 2005. Magnetite nanoparticles are suitable for MRI contrast (Bean et al, 1959, Koenig et al, 1987.…”

Section: Magnetic Resonance Imaging (Mri) Is a Non-invasive Techniquementioning

confidence: 99%

Tailored and Functionalized Magnetite Particles for Biomedical and Industrial Applications

Durdureanu-Angheluta¹,

Pinteală²,

Simionescu³

2012

Materials Science and Technology

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“…Several authors have proposed different analytical techniques, such as Calorimetry, Light Microscopy and Nuclear Magnetic Resonance (NMR), to characterize the matrix swelling process and the effects involved in drug-release (Gladden 1994;Gao, Skoug et al 1996;Richardson, Bowtell et al 2005; Thérien-Aubin, Baille et al 2005;Mikac, Kristl et al 2011;). …”

Section: Drug-release Mechanisms From Hydrophilic Matrix Systemsmentioning

confidence: 99%

High-amylose carboxymethyl starch matrices for oral sustained drug-release: In vitro and in vivo evaluation

Nabais

Brouillet

Kyriacos

et al. 2007

European Journal of Pharmaceutics and Biopharmaceutics

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Pharmaceutical applications of magnetic resonance imaging (MRI)

Cited by 196 publications

References 76 publications

Noninvasive Visualization of in Vivo Drug Delivery of Poly(l-glutamic acid) Using Contrast-Enhanced MRI

Noninvasive Visualization of in Vivo Drug Delivery of Poly(l-glutamic acid) Using Contrast-Enhanced MRI

Tailored and Functionalized Magnetite Particles for Biomedical and Industrial Applications

High-amylose carboxymethyl starch matrices for oral sustained drug-release: In vitro and in vivo evaluation

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