2017)R educing the dietary om ega-6 to om ega-3 polyunsaturated fatty acid ratio attenuated inflamm atory indices and sustained epithelial tight junction integrity in w eaner pigs housed in a poor sanitation condition. Animal Feed Science and Technology, 234 . pp. 312-320. Reducing the dietary omega-6 to omega-3 polyunsaturated fatty acid ratio attenuated inflammatory indices and sustained epithelial tight junction integrity in weaner pigs housed in a poor sanitation condition.Animal Feed Science and Technology http://dx.(J. M. Heo) †These authors have contributed equally to this work Highlights A total of 108 male pigs [Duroc × (Yorkshire × Landrace); initial BW 7.1 ± 0.5 kg] weaned at 21 days of age were randomly allocated to one of 3 dietary treatments and 2 environmental conditions (sanitary vs. unsanitary) (6 replicate pens per treatment, 3 pigs per pen) One pig per pen (n = 6) was euthanized on d 0, d 7 and d 14, to collect blood and small intestinal tissue samples Housing pigs in an unsanitary environment after weaning increased inflammatory responses and reduced growth performance, but reducing the n-6:n-3 PUFA ratio to 4:1 attenuated the inflammatory responses induced by the unsanitary environment.
ABSTRACTThe present study was conducted to determine the effect of reducing dietary n-6:n-3 PUFA ratio on the performance, inflammatory response and gut morphology of PWD challenged with sanitary and poor sanitary conditions in weaned pigs, and to test the hypotheses that (1) exposure to an poor sanitary environment will increase indices for Abbreviations: ADFI, average daily feed intake; ADG, average daily gain; ANOVA, analysis of variance; BW, body weight; COX-2, cyclooxygenase-2; CP, crude protein; D, dietary treatments; DE, digestible energy; DHA, docosahexaenoic acid; DM, dry matter; E, environmental condition (sanitary vs poor sanitary); ELISA, enzyme linked immunosorbent assay; EPA, eicosapentaenoic acid; FCR, feed conversion ratio; GE, gross energy; IL-1β, interleukin 1β; LTB4, leukotriene B4; N, nitrogen; n-6:n-3, omega-6 to omega-3; PGE2, prostaglandin E2; PPARγ, peroxisome proliferator-activated receptor-γ; PUFA, polyunsaturated fatty acid; PWD, post-weaning diarrhoea; SEM, standard error of mean; SID, standardised ileal digestible; TNF-α, tumor necrosis factor α; V:C, villous height: crypt depth.
