No abstract

Ca*'^ and Ca tôt were measured and compared al 2 years interval (SI and S2) in 45 normal volunteers; 26 females and 19 maies âge 20/65 years. For Ca** the mean dilTer ence between SI and S2 was small (0.009 mmol/l) butsignillcant (p <0.01). ForCa tôt the mean dilTerence between SI and S2 (0.06 mmol/l) was very significant (p < 0.001) due to the combination of various factors: technicai, sex ditïerence and proteins. In both séries (SI + S2) Ca'*"^ did not dilTer significantly between females and maies, whereas Ca tôt was signillcantly (p < 0.05) highcr in malcs (mean diircrence 0.06 mmol/l) for SI and non significant for S2. In 63 normal volunteers we cross correlated the factors of calcium homeostasis and showed significant relationship between Ca'^*/Ca tôt r = 0.428 (p < 0.001), Ca**/PTH r = 0.297 (p < 0.05), Ca tot/Proteins r = 0.518 (p < 0.001). The relationship between Ca tôt and PTH does not reach the level of significance. We compared Ca'^'^ and Ca tôt in rénal insufficiency (Rl)(n = 16), hyperparathyroidism surgically conlirmed (Hyper P) (n = 10), cancer wiih hypercalcemia (C) (n = 9) and in nomial volunteers (N) (n = 63). The relationship between Ca"'"^ and Ca tôt in the patho logie groups has significantly steeper slopcs than the control group (N), p < 0.05 for R] and C and p<0.0l for Hyper ?. The increase of the Ca**/Ca tôt ration in RI and Hyper P is positively correlated to PTH levels, ncralbumin variations neiiherpH and P04 variations could completely account for the increase of the ratio. The increase of Ca^*/Ca lot in cancer is independent of PTH and cannotentircly be explained by the albumin drop.