Factors affecting the determination of ionized calcium in blood

Brauman, J.; Delvigne, C; Deconinck, I.; Willems, D.

doi:10.3109/00365518309169076

Cited by 8 publications

(5 citation statements)

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“…There are various possible causes for the increase of C a+ + in patients with normal PTH: the concentration of total calcium, albumin [3] or H + in plasma [20], hypophos phatemia [11,21], reabsorption of extraskeleta! metastatic calcification [22], and calcium kidney tubular hyperreab sorption [8].…”

Section: Discussionmentioning

confidence: 99%

High Plasma Ionized Calcium with Normal PTH and Total Calcium Levels in Normal-Function Kidney Transplant Recipients

Vezzoli¹,

Elli²,

Palazzi³

et al. 1986

Nephron

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Hypercalcemia is a postrenal transplant complication. We found a high frequency of elevated plasma ionized calcium values (65.8%) in 41 normal-function renal graft recipients. In 8 patients increased free calcium was associated with high PTH levels, whereas in 19 PTH was not increased but free calcium was high. In the other 14 patients both free calcium and PTH were in the normal range. The mean transplant duration was different in the three groups: shorter in high PTH patients, longer in normal free calcium patients, intermediate in normal PTH and high free calcium patients. Our findings confirm that a condition of hyperparathyroidism persists in the first post-transplant period, and suggest that this complication evolves towards normalization of the blood chemistry values, passing through a condition of inappropriate PTH secretion with elevated plasma free calcium which in this period is the only marker of parathyroid hyperfunction.

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Section: Discussionmentioning

confidence: 99%

High Plasma Ionized Calcium with Normal PTH and Total Calcium Levels in Normal-Function Kidney Transplant Recipients

Vezzoli¹,

Elli²,

Palazzi³

et al. 1986

Nephron

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“…Heparin forms a stable chelation complex with cations that can reduce measured Na + and Ca 2+ values. 10,11 Traces of Ca 2+ were added to the syringes containing lithium heparin to adjust the measurements, but no adjustments were made for Na + . Thus, the measured Na + values could be lower than the actual values.…”

Section: Discussionmentioning

confidence: 99%

Clinical Performance of a Novel Portable epoc^™ Analyzer for Arterial Blood Gas and Electrolyte Testing in Operating Rooms

Sugino

Ishioka

Tachibana

et al. 2012

Medical Equipment Insights

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Background: A new blood gas analyzer (epoc™, Epocal Inc.) has recently been developed for the ambulatory monitoring of respiration and electrolyte balance. However, the accuracy of this instrument has not been fully elucidated. The present study compares the performance of the epoc™ analyzer and a conventional bench-top analyzer in operating rooms. Materials and Methods: Fifty blood samples were collected from anesthetized surgical patients and three samples were collected from volunteers into syringes containing lithium heparin. pH, pCO 2 , pO 2 , Na + , K + Ca 2+ , glucose, lactate and hemoglobin levels were measured using both the epoc™ and calibrated ABL700™ analyzers (Radiometer). Data were statistically analyzed using Pearson correlation coefficients and Bland-Altman plots. Results: Results showed excellent agreement between the values measured using the epoc™ analyzer and those obtained using the ABL700™ analyzer, except for Na + . Conclusions:The epoc™ analyzer is useful in clinical settings, including operating rooms.

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“…Urine samples were collected in the morning after at least 12 hours of fasting and then after 24 hours. Serum parathyroid hormone (PTH) levels were determined with the Elecsys PTH (1-84) test (Co-basÒ, Roche Diagnostics GmbH, Mannheim, Germany pH ) , the following formulations were used [20][21][22][23][24][25] :…”

Section: Patients and Methods Study Populationmentioning

confidence: 99%

Calcium–phosphate metabolism disturbances in patients with significant mitral regurgitation

Możeńska¹,

Bil²,

Segiet³

et al. 2018

Polish Archives of Internal Medicine

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INTRODUCTION Although there are several known risk factors of cardiovascular diseases (CVDs), the search for new factors continues. In recent years, clinical trials have reported vitamin D and other calcium (Ca) and phosphate (P) metabolism disorders as potential new cardiovascular risk factors, but literature data on this association are limited. OBJECTIVES We aimed to assess the extent of Ca and P metabolism disorders in patients with mitral regurgitation (MR) and potential role of these disorders as risk factors of CVD. PATIENTS AND METHODS We enrolled adult patients with significant MR (vena contracta >3 mm, effective orifice area >0.2 cm2, and MR volume >30 ml/s) hospitalized in our department between July and September 2013. Anthropometric data were collected. Moreover, all patients underwent blood and urine analysis, transthoracic echocardiography, and 6‑minute walking test. RESULTS A total of 99 patients were enrolled (median age, 75 years; [Q1-Q3, 66.0-81.5]; women, 35.4%). The median serum Ca level corrected by albumin was 3.22 mmol/l [Q1-Q3, 3.14-3.27]. The mean (SD) serum ionized Ca level corrected by pH was 1.05 (0.08) mmol/l. The median levels of parathyroid hormone (PTH) and 25(OH)D3 were 63.10 pg/ml [Q1-Q3, 40.95-88.55] and 14.80 ng/ml [Q1-Q3, 9.93-20.12], respectively. Patients with a history of heart failure (HF) with reduced ejection fraction (New York Heart Association class IV), shorter distance in the 6‑minute walking test, lower left ventricular ejection fraction, and larger left ventricular end‑diastolic diameter had significantly higher probability of elevated PTH levels. CONCLUSIONS Disorders of Ca and P metabolism in patients with significant MR are a noteworthy clinical problem. Our study is the first to systematically describe these disorders in patients with CVD. However, larger studies are needed to confirm the significance of our results.

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Factors affecting the determination of ionized calcium in blood

Cited by 8 publications

References 0 publications

High Plasma Ionized Calcium with Normal PTH and Total Calcium Levels in Normal-Function Kidney Transplant Recipients

High Plasma Ionized Calcium with Normal PTH and Total Calcium Levels in Normal-Function Kidney Transplant Recipients

Clinical Performance of a Novel Portable epoc^™ Analyzer for Arterial Blood Gas and Electrolyte Testing in Operating Rooms

Calcium–phosphate metabolism disturbances in patients with significant mitral regurgitation

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Factors affecting the determination of ionized calcium in blood

Cited by 8 publications

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High Plasma Ionized Calcium with Normal PTH and Total Calcium Levels in Normal-Function Kidney Transplant Recipients

High Plasma Ionized Calcium with Normal PTH and Total Calcium Levels in Normal-Function Kidney Transplant Recipients

Clinical Performance of a Novel Portable epoc™ Analyzer for Arterial Blood Gas and Electrolyte Testing in Operating Rooms

Calcium–phosphate metabolism disturbances in patients with significant mitral regurgitation

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Product

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Clinical Performance of a Novel Portable epoc^™ Analyzer for Arterial Blood Gas and Electrolyte Testing in Operating Rooms