Comparing the terms of the two series lb-34b it can be seen that the poly-halogenderivatives 3 lb-33b are the most active substances while the nitro-derivatives 13b-16b, whose antimicrobial action is less pronunced, show the fastest decomposition rate.Therefore, these do not appear to be a direct, univocal correlation between the activity and the physicochemical parameter in question, even though the most active compounds were anyhow very reactive under our experimental conditions. Chlordiazepoxid wird an der Amidingruppe durch Protonierung hinreichend geschutzt, um eine Reaktion mit Isocyanaten nur an der Nifrongruppe unter [3+21 Cycloaddition zu Derivaten des 1,2,4lOxadiazo-1012,3-dll 1,4lbenzodiazepin-2-on eintreten zu lassen. [3 +Z]Cyeloaddition of Chlordiazepoxide with Isocyanates Chlordiazepoxide hydrochloride is attacked by isocyanates on the nitrone moiety only. Derivatives of I1,2,4]0xadiazolo[2,3-dl[ 1,4] benzodiazepine-2-one are formed. **) Herrn Prof. Dr. Herbert Oelschlager in herzlicher Verbundenheit zum 65. Geburtstage. 0365-6233/87/0303-210 S 02.50/0 0 VCH Verlagsgesellschaft mbH, 0-6940 Weinheim, 1987
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