In-vitro dissolution tests were c a r r i e d out with t a b l e t s prepared from d i f f e r e n t p a r t i c l e s i z e ranges o f metronidazole. (Methylcellulose, polyvinyl pyrrolidone -(FVP) , potato starch and g e l a t i n ) on the drug release were investigated under s i m i l a r conditions, Comprimates Influence of tablet binding agents containing PVP and drug with p a r t i c l e size 1.75 lun ( i n l a c t o s e mixture) gave optimum r e s u l t s These findings m Y open new Ways of formulating a metronidazole t a b l e t exhibiting improved drugl i b e r a t i o n , subsequently with a better b i o a v a i l a b i l i t y than the K L X d -Tablet manufactured i n Hungary, 1085
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