This trial has been carried out by thirteen National Leprosaria and the National Institute for Leprosy Research since October, 1971.Observation has been made clinically, bacteriologically, histopathologically and serologically at regular intervals through the trial.Pure lepromatous cases were selected and divided into following five groups, i.e., Group A, B, C (C-1, C-2) and D. Group A consisted of untreated new cases, and Group B relapsed cases. Group C consisted of so-called resistant cases ; and divided into C-1 and C-2 according to the duration of the past treatment. Group C-1 were cases showing poor recovery in B.I. though treated regularly more than five years. Group C-2 were clinically aggravated cases by regular treatment more than one year. Group D
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