The impact of unfavorable factors of aviation flight causes a significant strain in the flight crew of the functional state of the body, including various parts of the immune system. To date, research on the problems of interaction between different parts of the immune system in flight personnel in the process of professional adaptation is practically absent. In this regard, a study was conducted of immunological reactivity according to calculated data from 100 pilots of fighter aircraft and 102 pilots of other types of aircraft. The data obtained indicate significant dissociation of the flight composition in the immune system and changes in its reactivity. Studies of immunological reactivity in terms of integral leukocyte indices seem promising and, in combination with other methods of clinical and functional diagnostics, will expand the possibilities of assessing the overall functional status of pilots in the process of medical examination.
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