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Hyperuricemia is commonly recognized in adolescents and adults with cyanotic congenital heart disease. We report a case of a male infant with hyperuricemia, Taussig-Bing anomaly, and interruption of the aortic arch. The patient underwent correction of interrupted aortic arch and pulmonary arterial banding at the age of 7 days. Hyperuricemia appeared when he was 2 months old (max 17.7 mg/dl) and persisted until he underwent a Jatene operation at the age of 10 months. The hyperuricemia improved gradually after the disappearance of hypoxia and polycythemia. The laboratory findings suggest that hyperuricemia can result from uric acid overproduction due to secondary polycythemia, impairment of uric acid excretion by the kidney, or the acceleration of anaerobic metabolism. Allopurinol and benzbromarone together were partially effective treatments for hyperuricemia in this patient with cyanotic congenital heart disease.

A case is presented in which 7 months after the first mitral valve replacement (MVR) the malfunction of a Bjork-Shiley valve prosthesis was supposed and the thrombosed valve prosthesis was 2 months later successfully replaced. For the detection of the malfunction of the valve prosthesis echocardiography was especially useful. Additional Indexing Words: Echocardiography Phonocardiography Anticoagulant therapy Dipyridamole Urokinase JORK-SHILEY valve prosthesis has recently been used widely for its hemodynamical excellences and some serious complications of this prosthesis were reported.1),2) This paper is a report on the thrombosed Bjork-Shiley mitral valve prosthesis. We could detect its malfunction echocardiographically and phonocardiographically and performed the replacement successfully. CASE REPORT A 38-year-old woman was operated upon in February 1974 for severe mitral stenosis. The Bjork-Shiley tilting disc valve (23 MBP) was used for valve replacement of the highly calcified mitral valve. The patient's recovery from MVR was uneventful. The echocardiogram of the first postoperative day showed no remarkable changes. Valve amplitude was 10mm, diastolic descent rate was 20 mm/sec, left atrial dimension was 38mm and no changes were seen in the echo of the mitral annulus (Fig.1). Anticoagulant therapy was started on the third postoperative day with heparin. Since the 5th postoperative day, warfarin and dipyridamole (375mg/day) were given instead of heparin. After her discharge she visited our clinic every 2 weeks