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Introduction: Anesthetic therapy in patients with epidermolysis bullosa has several peculiarities. Some choices in the anesthetic procedure can be understood as imprudent, but such isolated or unrelated measures can make a difference in saving them. Report: The patient presented intermittent remission / exacerbation with infected lesions on the skin. A total of 37 anesthetic / surgical procedures were performed, and the main alterations and peculiarities related to the difficulty of monitoring, obtaining peripheral venous access, hypothermia, analgesia and difficult airway were described. Conclusions: Hypothermia, difficult airway, difficulty in venous access and monitoring, and infection were frequent problems. Dealing with these procedures repeatedly required of the team a series of adaptations and extrapolations in the absence of data in the literature.
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