Effects of Intra-Abdominal Pressure in Rat Lung Tissue After Pneumoperitoneum

Abstract

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Effects of deep neuromuscular block with low-pressure pneumoperitoneum on respiratory mechanics and biotrauma in a steep Trendelenburg position

“…Increased IAP itself causes inflammatory-induced lung damage after PP 8 , 14 , although laparoscopy has clear benefits in terms of reduced inflammatory response compared to open surgery 6 , 15 . Recently, it has been reported that IL 1-β, IL-6, and TNF-α levels increased in lung tissue as IAP increased, which was confirmed by histologic examination 14 .…”

“…Increased IAP itself causes inflammatory-induced lung damage after PP 8 , 14 , although laparoscopy has clear benefits in terms of reduced inflammatory response compared to open surgery 6 , 15 . Recently, it has been reported that IL 1-β, IL-6, and TNF-α levels increased in lung tissue as IAP increased, which was confirmed by histologic examination 14 . Among randomized controlled trials in humans, Schietroma et al observed a significant decrease in IL-1, IL-6, and CRP levels 16 , and Basgual et al observed a lower increase in IL-6 level up to 24 h postoperatively in low-pressure PP compared to high-pressure PP 17 .…”

“…The current study has a few limitations. First, although the high IAP during mechanical ventilation increased inflammatory markers in the lungs 14 , the increase in systemic inflammatory cytokines might have resulted from other sites also. In rats, PP increased levels of IL-6 and TNF-α in the peritoneum or abdominal organs 34 , 35 .…”