<span>A dosimetry study of in vitro and in vivo trials system in thermal column of Kartini Reactor for Boron Neutron Capture Therapy (BNCT) facility has been conducted by using the Monte Carlo N-Particle Extended (MCNPX) software. Source of neutron originated from the 100 kW reactor which has been modified by the previous researcher. Models have been made by using simple geometries to represent tissues. Models of in vitro have been made by 4 spheres each has 1 cm diameter to represent tumour, whereas in vivo by 4 cylinders each has 6 cm length, 3 cm diameter, and breast soft tissue material with 1 cm sphere each located in the center of the cylinders to represent models of mouse with tumour. An increase in value of the boron concentration will increase the value of dose rate as well, then the exposure time should be shorter. The exposure times (in minutes) of in vitro trials for 20, 25, 30, 50, 75, 100, 125, and 150 μg boron/g tissues are 117.77, 117.77, 117.07, 115.69, 114.02, 112.39, 110.80, and 109.27. Whereas the exposure times of in vivo trials are 163.58, 162.78, 161.98, 158.88, 155.16, 151.61, 148.22, dan 144.98. In vitro trials have greater values of dose rate so that in vitro trials have shorter exposure time.</span>
Cancer is a malignant tumor that destroys healthy cells. Cancer treatment can be done by several methods, one of which is BNCT. BNCT uses 10B target which is injected into the human body, then it is irradiated with thermal or epithermal neutrons. Nuclear reaction will occur between boron and neutrons, producing alpha particle and lithium-7. The dose is estimated by how much boron and neutron should be given to the patient as a sum of number of boron, number of neutrons, number of protons, and number of gamma in the reaction of the boron and neutron. To calculate the dose, the authors simulated the reaction with Monte Carlo N Particle-X computer code. A water phantom was used to represent the human torso, as 75% of human body consists of water. Geometry designed in MCNPX is in cubic form containing water and a cancer cell with a radius of 2 cm. Neutron irradiation is simulated as originated from Kartini research reactor, modeled in cylindrical form to represent its aperture. The resulting total dose rate needed to destroy the cancer cell in GTV is 2.0814×1014 Gy.s (76,38%) with an irradiation time of 1,4414×10-13 s. In PTV the dose is 5.2295×1013 Gy.s (19,19%) with irradiation time of 5.7367×10-13 s. In CTV, required dose is 1.1866×1013 Gy.s (4,35%) with an irradiation time of 2.5283×10-12 s. In the water it is 1.9128×1011 Gy.s (0,07%) with an irradiation time of 1,5684×10-10 s. The irradiation time is extremely short since the modeling is based on water phantom instead of human body.Keywords: BNCT, Dose, Cancer, Water Phantom, MCNPX
A study of the assessment criteria covers the synthesis and characterization of agent and test their biological effectiveness as boron neutron capture therapy (BNCT) agents in cancer treatment. The cellular uptake of this agent into the glioblastoma cells was assessed by boron analysis (ICP-MS) and by fluorescence imaging (confocal microscopy). The agent enters the glioblastoma cells exhibiting a similar profile, i.e., preferential accumulation in the cytoskeleton and membranes and a low cytotoxic activity (IC<sub>50</sub> values higher than 200 μM). The cytotoxic activity and cellular morphological alterations after neutron irradiation in the Research Reactor (>10<sup>7</sup> neutrons cm<sup>−2</sup> s<sup>−1</sup>) were assessed by the MTT assay and by electron microscopy (TEM). Post neutron irradiation revealed that BNCT has a higher cytotoxic effect on the glioblastoma cells. Results provide a strong rationale for considering one of these compounds as a lead candidate for a new BNCT agent.
Liver cancer was the third leading cause of death from cancer in 2020 with 830,180 deaths worldwide. Radiotherapy is a common treatment method for liver cancer. Technological advances presented proton therapy and boron neutron capture therapy (BNCT) as alternatives with a lower dose on healthy organs. The objective of this research is to get a good dose distribution with higher tumor dose and lower healthy organ dose in proton therapy. A comparison with BNCT is done to get a better understanding of how both methods deliver the dose to treat the cancer while minimizing healthy organ doses. The research simulated proton therapy for cancer liver with Particle and Heavy Ions Transport Code System (PHITS), and a literature review for BNCT. The effectiveness of both methods were compared by tumor dose and liver dose. The optimal tumor dose for proton therapy is 86.01 Gy (W) with 0.67 Gy (W) liver dose. Proton therapy can replace conventional radiotherapy for tumors with complex shapes in dose delivery by utilizing its dose profile, while BNCT can give better tumor control on patients previously treated with conventional radiotherapy.
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