Oxytocin (OT), a hormone most commonly associated with labor and lactation, may have a wide variety of physiological and pathological functions, which makes OT and its receptor potential targets for drug therapy. In this review, we highlight the newly discovered metabolic role of OT in diabetes and its complication, such as diabetic osteopathy. OT may have positive metabolic effects; this is based on the change in glucose metabolism, lipid profile, and insulin sensitivity. It may modify glucose uptake and insulin sensitivity both through direct and indirect effects. It may also cause regenerative changes in diabetic pancreatic islet cells. Moreover, it has an anabolic effect on the bone biology. So, the activation of the OT receptor pathway by infusion of OT, OT analogs, or OT agonists may represent a promising approach for the treatment of diabetes and some of its complications, including diabetic osteopathy.
The results suggest that activation of the oxytocin receptor (OTR) pathway by infusion of OT, OT analogs, or OT agonists may represent a promising approach for the treatment of diabetes and some of its complications, including diabetic osteopathy.
ISBN: 978-1-4244-5309-2 - WOSInternational audienceThe elaboration of new and innovative systems such as MPSoC (Multiprocessor System on Chip) which are made up of multiple processors, memories and IPs lies on the designers to achieve a complex codesign work. Specific tools and methods are needed to cope with the increasing complexity of both algorithms and platforms. Our approach to design such systems is based on the usage of a high level of abstraction language called RVC CAL. This language is dataflow oriented and thus points out the concurrency and parallelism of algorithms. Moreover CAL is supported by the OpenDF simulator and by two code generators called CAL2C (software generator) and CAL2HDL (hardware generator). The MPEG expert group has recently elaborated the Reconfigurable Video Coding (RVC) standard which defines the RVC CAL language as reference for MPEG video decoder descriptions. This paper introduces the opportunities to design an innovative system involving hardware and software IPs, embedded processors and memories from a CAL model. Practical results on a FPGA are provided with a codesign solution of an MPEG4 Simple Profile (SP)
The activities of N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT) and the melatonin concentration of the Harderian glands of two strains of Syrian hamster females (outbred and inbred LSH/SsLak) exposed to two different photoperiods (14:10 h and 8:16 h) were studied. The Harderian glands of the inbred hamsters showed greater NAT activity than those of the outbred animals. On the other hand, the glands of the outbred hamsters exhibited higher HIOMT activity and melatonin content than those of the inbred LSH/SsLak. Short photoperiod exposure, which produced gonadal regression in the inbred but not in the outbred hamsters, decreased the NAT activity in the inbred animals to the levels of the outbred. HIOMT activity was not affected by the lighting conditions. After the exposure to short days, the melatonin content of the inbred hamster Harderian glands increased to that in the outbred animals. Daily melatonin injections, which caused gonadal regression in the LSH/SsLak but not in the outbred hamsters, did not stimulate the effect of the short photoperiod on the Harderian gland NAT activity and melatonin content of the inbred hamsters.
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