Oxytocin as a novel therapeutic option for type I diabetes and diabetic osteopathy

Elabd, Seham; Sabry, Ismail; Mohasseb, Magda; Algendy, Ashraf

doi:10.4149/endo_2014_02_87

Cited by 23 publications

(34 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous translational studies stemming from in vitro models to in vivo diabetic models have made headway in developing these therapeutic approaches that specifically target osteoblasts and/or osteoclasts. Among those are the treatments with insulin, PTH, oxytocin, zinc supplement, and sclerostin antibody that have stimulatory effects on osteoblastogenesis and modulatory effects on osteoclast function and formation, which improve bone loss and/or healing . With the emergence of the osteocyte as a key player in diabetic skeletal complications, we expect that future preclinical and translational studies will focus on development and testing of novel osteocyte‐targeted therapeutic interventions, either as an alternative or in combination with osteoanabolic approaches to improve treatment of skeletal dysfunction in diabetic patients.…”

Section: Clinical Relevancementioning

confidence: 99%

A new perspective on mechanisms governing skeletal complications in type 1 diabetes

Seref‐Ferlengez

Suadicani

Thi

2016

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

This review focuses on bone mechanobiology in type 1 diabetes (T1D), an area of research on diabetes-associated skeletal complications that is still in its infancy. We first provide a brief overview of the deleterious effects of diabetes on the skeleton and of the knowledge gained from studies with rodent models of T1D. Second, we discuss two specific hallmarks of T1D, low insulin and high glucose, and address the extent to which they affect skeletal heath. Third, we highlight the mechanosensitive nature of bone tissue and the importance of mechanical loading for bone health. We also summarize recent advances in bone mechanobiology that implicate osteocytes as the mechanosensors and major regulatory cells in the bone. Finally, we discuss recent evidence indicating that the diabetic bone is “deaf” to mechanical loading and that osteocytes are central players in mechanisms that lead to bone loss in T1D.

show abstract

Section: Clinical Relevancementioning

confidence: 99%

A new perspective on mechanisms governing skeletal complications in type 1 diabetes

Seref‐Ferlengez

Suadicani

Thi

2016

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…21,22 In recent research, oxytocin has shown positive metabolic effects on insulin sensitivity, glucose metabolism, and lipid profile in diabetic rats. 23 Moreover, it has an anabolic effect on bone biology. 24,25 As we know, UC is implied as a systemic disease associated with diabetes mellitus, hypertension, gout, and osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Association Between Recurrence of Urinary Calculi and Childbirth: A Population-Based Case-Control Study

Shih

Chiang

Liao

et al. 2016

International Surgery

View full text Add to dashboard Cite

We examined the recurrence rate of urinary calculi (UC) in women after childbirth. The recurrence of UC is common, but no previous studies mentioned the risk of recurrence after childbirth. We performed a nationwide population-based cohort study to investigate whether childbirth could correlate with the recurrence of UC by using data from the National Health Insurance Research Database in Taiwan. Nulliparous women (age !20 years) receiving a diagnosis of first episode of UC between 2000 and 2002 were enrolled. We recorded the events of recurrence between parous patients (n ¼ 737) and matched-control nulliparous patients (n ¼ 737). The average ages for parous patients and controls were 27.41 and 27.54, respectively. The recurrence rate was 11.67% (86 of 737) in the childbirth cohort group and 21.57% (159 of 737) in the nonchildbirth cohort group. The childbirth cohort group was associated with a significantly decreased risk of secondary UC (adjusted hazard ratio, 0.45; 95% confidence interval, 0.35-0.59) compared with those who did not deliver a child. This relationship should be studied further.

show abstract

“…For example, OT can improve autism, depression, and other mental disorders associated with immune disorders (71) and increase resistance of enterocyte apoptosis (48) while reducing the apoptosis of rat mesenchymal stem cells (20), and promoting regenerative capacity of skeletal muscle (46) and pancreatic islet cells of diabetic rats (47). …”

Section: Immune Functions Of the Ossmentioning

confidence: 99%

Approaches Mediating Oxytocin Regulation of the Immune System

Wang

et al. 2017

Front. Immunol.

View full text Add to dashboard Cite

The hypothalamic neuroendocrine system is mainly composed of the neural structures regulating hormone secretion from the pituitary gland and has been considered as the higher regulatory center of the immune system. Recently, the hypothalamo-neurohypophysial system (HNS) emerged as an important component of neuroendocrine–immune network, wherein the oxytocin (OT)-secreting system (OSS) plays an essential role. The OSS, consisting of OT neurons in the supraoptic nucleus, paraventricular nucleus, their several accessory nuclei and associated structures, can integrate neural, endocrine, metabolic, and immune information and plays a pivotal role in the development and functions of the immune system. The OSS can promote the development of thymus and bone marrow, perform immune surveillance, strengthen immune defense, and maintain immune homeostasis. Correspondingly, OT can inhibit inflammation, exert antibiotic-like effect, promote wound healing and regeneration, and suppress stress-associated immune disorders. In this process, the OSS can release OT to act on immune system directly by activating OT receptors or through modulating activities of other hypothalamic–pituitary–immune axes and autonomic nervous system indirectly. However, our understandings of the role of the OSS in neuroendocrine regulation of immune system are largely incomplete, particularly its relationship with other hypothalamic–pituitary–immune axes and the vasopressin-secreting system that coexists with the OSS in the HNS. In addition, it remains unclear about the relationship between the OSS and peripherally produced OT in immune regulation, particularly intrathymic OT that is known to elicit central immunological self-tolerance of T-cells to hypophysial hormones. In this work, we provide a brief review of current knowledge of the features of OSS regulation of the immune system and of potential approaches that mediate OSS coordination of the activities of entire neuroendocrine–immune network.

show abstract

Oxytocin as a novel therapeutic option for type I diabetes and diabetic osteopathy

Abstract: The results suggest that activation of the oxytocin receptor (OTR) pathway by infusion of OT, OT analogs, or OT agonists may represent a promising approach for the treatment of diabetes and some of its complications, including diabetic osteopathy.

Cited by 23 publications

References 41 publications

A new perspective on mechanisms governing skeletal complications in type 1 diabetes

A new perspective on mechanisms governing skeletal complications in type 1 diabetes

Association Between Recurrence of Urinary Calculi and Childbirth: A Population-Based Case-Control Study

Approaches Mediating Oxytocin Regulation of the Immune System

Contact Info

Product

Resources

About