Turkey. Critical revision, final approval of the manuscript. ABSTRACT PURPOSE:To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats. METHODS:Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 µg/kg Dex (group 3) and 100 µg/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses. RESULTS:Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles: Dex 100 µg/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 µg/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations. CONCLUSION:The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen's scoring system between groups at both sides.

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Background and Aim: This study aimed to determine the mean platelet volume (MPV) and platelet distribution width (PDW) values of intensive care patients, and show the relationship between these parameters and mortality. Material and Method: In the present study, 284 patients who were hospitalized in the intensive care unit were retrospectively analyzed. MPV and PDW values of the patients when they first hospitalized, their last MPV and PDW values before they died or were discharged, their ages and duration of ICU period were recorded. Results: There was no statistically significant difference between the first and last values of MPV and PDW in the surviving patient group. Similarly, PDW values did not change in the group of patients who died (p> 0.05). However, the last MPV values were significantly higher in the deceased patient group than the first MPV values (p <0.05). In this study, when the age, length of stay in the intensive care unit, MPV and PDW values were compared, the most important factor was found to be an increase in MPV. Conclusion: This study showed that MPV increase in intensive care patients may be closely related to mortality.

The aim of this study is to evaluate hysterectomy procedures performed for benign conditions in terms of indications and histopatho-logical results. Retrospective analysis of 32 hysterectomy cases, which were performed between January 2011 and Decem-ber 2012, was conducted to review indications and histo-pathological diagnoses. The most frequent indications for hysterectomy were abnormal uterine bleeding myoma uteri and endometrial hyperplasia, respectively. Other clinical indications were adenomyosis and uterine prolapse .The most common histopathological diagnoses reported for hysterectomy specimens were leiomyoma adenomyosis and endometrial hyperplasia respecti-vely. Endometrial polyp was diagnosed in specimens of patients. Endometrial atrophy was reported in patients. Cervical histopathology of hysterectomy materials revealed chronic cervicitis in of the patients. Due to the high coincidence of myoma uteri and endometrial hyperplasia, endometrial sampling should be performed in patients who are being considered for hysterectomy.

Pressure ulcers are a common problem in intensive care unit (ICU). Recently, topical sevoflurane has been used especially for treatment of venous ulcers and infected skin ulcers. We present a case of topical sevoflurane treatment of a pressure ulcer. Treatment was applied for one month without any antibiotic supplementation. After one month, the ulcer size was decreased, necrotic tissues were cleared, and wound cultures were negative. There are three beneficial effects of local sevoflurane treatment: good analgesic action, antibiotic effects, and acceleration of wound healing. These beneficial effects may make sevoflurane an alternative treatment for pressure ulcers in an ICU.