Introduction: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. Oxidative stress caused by Reactive oxygen species (ROS) plays a crucial role in the pathogenesisis of leprosy.Objective: To measure the enzymatic oxidative stress indicators and oxidative stress index in patients of leprosy and compare them with healthy age & sex matched controls.Materials and Methods: In this prospective study 30 untreated leprosy patients were included in the study and matched with 60 healthy controls. Biochemistry estimation was done with blood samples and MDA (lipid peroxidation), Nitric oxide (NO), (SOD) Superoxide dismutase (antioxidant enzyme), total oxidant status (TOS), total antioxidant status(TAS) and oxidative stress index (OSI) were estimated.Results: Highly significant rise (p<0.0001) in serum MDA, NO, TOS and OSI was seen in leprosy patients when compared with controls with highly significant decline in SOD and TAS.Conclusion: The study confirms the oxidative stress in leprosy and suggests antioxidant therapy may be used as an adjuvant in the treatment of leprosy along with MDT.
Introduction: Isotopic phenomenon refers to the occurrence of a new dermatosis at the site of previously healed dermatosis. A number of factors including viral, neural, vascular, and immunologic factors have been implicated in the causation of this peculiar phenomenon but none has been proven conclusively. We report a case where leprosy developed at the site of psoriatic lesion previously treated with medical therapy. Case Report: A 50 years old male presented with chief complaints of erythematous, mildly itchy scaly lesions all over the body with a history of relapses and remissions for last 20 years. After confirming the diagnosis of psoriasis with leprosy, patient was managed as an inpatient with oral hypoglycemic drugs along with multibacillary multi drug therapy. For psoriasis, patient was prescribed topical corticosteroids along with emollients over thick scaly lesions. Conclusion: This case has been reported due to the rarity of Wolf’s isotopic phenomenon and the coexistence of psoriasis with leprosy. The existing sporadic cases in literature which question the mutually exclusive relationship of leprosy and psoriasis needs further evaluation.
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